Impact of KRAS and EGFR Gene Mutations on Recurrence and Survival in Patients with Surgically Resected Lung Adenocarcinomas

Background Oncogenic gene mutations observed in lung adenocarcinomas, such as epidermal growth factor receptor ( EGFR ) and KRAS , have some predictive value for chemotherapeutic drugs or EGFR–tyrosine kinase inhibitors. However, the influence of these gene alterations on patients’ prognosis remains...

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Veröffentlicht in:	Annals of surgical oncology 2012-07, Vol.19 (Suppl 3), p.347-354
Hauptverfasser:	Sonobe, Makoto, Kobayashi, Masashi, Ishikawa, Masashi, Kikuchi, Ryutaro, Nakayama, Ei, Takahashi, Tsuyoshi, Menju, Toshi, Takenaka, Kazumasa, Miyahara, Ryo, Huang, Cheng-Long, Okubo, Kenichi, Bando, Toru, Date, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Codon Disease-Free Survival Exons Female Genes, Neoplasm Humans Kaplan-Meier Estimate Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Mutagenesis, Insertional Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - therapy Oncology Point Mutation Proportional Hazards Models Protein Kinase Inhibitors - administration & dosage Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Retrospective Studies Sequence Deletion Surgery Surgical Oncology Time Factors Translational Research and Biomarkers
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