A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata
From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(－) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), berg...
Gespeichert in:
| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2012/08/01, Vol.60(8), pp.1072-1075 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1075 |
|---|---|
| container_issue | 8 |
| container_start_page | 1072 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 60 |
| creator | Dongfack, Marlise Diane Jiofack Lallemand, Marie-Christine Kuete, Victor Mbazoa, Céline Djama Wansi, Jean-Duplex Trinh-van-Dufat, Hanh Michel, Sylvie Wandji, Jean |
| description | From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(－) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii. |
| doi_str_mv | 10.1248/cpb.c12-00279 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1032610670</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1032610670</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-a7a1c5410a69b35b049fce5d3a2db42a982e7fc96f2ca9cd8a1045f5f27277b33</originalsourceid><addsrcrecordid>eNpdkMtKxDAUQIMoOj6WbiXgxk01jzZpl8PgqCC6UMFduE1TJ0NfJqmjf290dAQ3uYscDvcehI4pOacszS_0UJ5ryhJCmCy20ITyVCYZY3wbTQghRcK44Hto3_tlRDIi-S7aYywXXFI-Qc9TfGdW-GFY2O6lb-xgKwxdheejg67X_diCs53HKxsWeNoF21rt-tJCg6c62DcbPnDt-hbPrR49Nu_gB-MgwCHaqaHx5uhnHqCn-eXj7Dq5vb-6mU1vE51REhKQQHWWUgKiKHlWkrSotckqDqwqUwZFzoysdSFqpqHQVQ6UpFmd1UwyKUvOD9DZ2ju4_nU0PqjWem2aBjrTj15RwpmgREgS0dN_6LIfXRe3UzQVUZuzVEQqWVPxTu-dqdXgbKzwEVXqK7mKyVVMrr6TR_7kxzqWrak29G_jCMzWwNIHeDEbAFywujHfOkFU_vVstH-_C3DKdPwTla2Uhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1460458246</pqid></control><display><type>article</type><title>A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Free Full-Text Journals in Chemistry</source><creator>Dongfack, Marlise Diane Jiofack ; Lallemand, Marie-Christine ; Kuete, Victor ; Mbazoa, Céline Djama ; Wansi, Jean-Duplex ; Trinh-van-Dufat, Hanh ; Michel, Sylvie ; Wandji, Jean</creator><creatorcontrib>Dongfack, Marlise Diane Jiofack ; Lallemand, Marie-Christine ; Kuete, Victor ; Mbazoa, Céline Djama ; Wansi, Jean-Duplex ; Trinh-van-Dufat, Hanh ; Michel, Sylvie ; Wandji, Jean</creatorcontrib><description>From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(－) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c12-00279</identifier><identifier>PMID: 22863713</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>antimicrobial activity ; Bacillus cereus - drug effects ; Candida albicans - drug effects ; Escherichia coli - drug effects ; Ficus - chemistry ; Ficus exasperata ; furanocoumarin ; Furocoumarins - chemistry ; Furocoumarins - isolation & purification ; Furocoumarins - pharmacology ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Microsporum - drug effects ; Molecular Structure ; Moraceae ; Plant Bark - chemistry ; Plant Extracts - pharmacology ; Spectrometry, Mass, Electrospray Ionization ; sphingolipid ; Sphingolipids - chemistry ; Sphingolipids - isolation & purification ; Sphingolipids - pharmacology</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2012/08/01, Vol.60(8), pp.1072-1075</ispartof><rights>2012 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-a7a1c5410a69b35b049fce5d3a2db42a982e7fc96f2ca9cd8a1045f5f27277b33</citedby><cites>FETCH-LOGICAL-c510t-a7a1c5410a69b35b049fce5d3a2db42a982e7fc96f2ca9cd8a1045f5f27277b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22863713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dongfack, Marlise Diane Jiofack</creatorcontrib><creatorcontrib>Lallemand, Marie-Christine</creatorcontrib><creatorcontrib>Kuete, Victor</creatorcontrib><creatorcontrib>Mbazoa, Céline Djama</creatorcontrib><creatorcontrib>Wansi, Jean-Duplex</creatorcontrib><creatorcontrib>Trinh-van-Dufat, Hanh</creatorcontrib><creatorcontrib>Michel, Sylvie</creatorcontrib><creatorcontrib>Wandji, Jean</creatorcontrib><title>A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(－) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.</description><subject>antimicrobial activity</subject><subject>Bacillus cereus - drug effects</subject><subject>Candida albicans - drug effects</subject><subject>Escherichia coli - drug effects</subject><subject>Ficus - chemistry</subject><subject>Ficus exasperata</subject><subject>furanocoumarin</subject><subject>Furocoumarins - chemistry</subject><subject>Furocoumarins - isolation & purification</subject><subject>Furocoumarins - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Microbial Sensitivity Tests</subject><subject>Microsporum - drug effects</subject><subject>Molecular Structure</subject><subject>Moraceae</subject><subject>Plant Bark - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>sphingolipid</subject><subject>Sphingolipids - chemistry</subject><subject>Sphingolipids - isolation & purification</subject><subject>Sphingolipids - pharmacology</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtKxDAUQIMoOj6WbiXgxk01jzZpl8PgqCC6UMFduE1TJ0NfJqmjf290dAQ3uYscDvcehI4pOacszS_0UJ5ryhJCmCy20ITyVCYZY3wbTQghRcK44Hto3_tlRDIi-S7aYywXXFI-Qc9TfGdW-GFY2O6lb-xgKwxdheejg67X_diCs53HKxsWeNoF21rt-tJCg6c62DcbPnDt-hbPrR49Nu_gB-MgwCHaqaHx5uhnHqCn-eXj7Dq5vb-6mU1vE51REhKQQHWWUgKiKHlWkrSotckqDqwqUwZFzoysdSFqpqHQVQ6UpFmd1UwyKUvOD9DZ2ju4_nU0PqjWem2aBjrTj15RwpmgREgS0dN_6LIfXRe3UzQVUZuzVEQqWVPxTu-dqdXgbKzwEVXqK7mKyVVMrr6TR_7kxzqWrak29G_jCMzWwNIHeDEbAFywujHfOkFU_vVstH-_C3DKdPwTla2Uhw</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Dongfack, Marlise Diane Jiofack</creator><creator>Lallemand, Marie-Christine</creator><creator>Kuete, Victor</creator><creator>Mbazoa, Céline Djama</creator><creator>Wansi, Jean-Duplex</creator><creator>Trinh-van-Dufat, Hanh</creator><creator>Michel, Sylvie</creator><creator>Wandji, Jean</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata</title><author>Dongfack, Marlise Diane Jiofack ; Lallemand, Marie-Christine ; Kuete, Victor ; Mbazoa, Céline Djama ; Wansi, Jean-Duplex ; Trinh-van-Dufat, Hanh ; Michel, Sylvie ; Wandji, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-a7a1c5410a69b35b049fce5d3a2db42a982e7fc96f2ca9cd8a1045f5f27277b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>antimicrobial activity</topic><topic>Bacillus cereus - drug effects</topic><topic>Candida albicans - drug effects</topic><topic>Escherichia coli - drug effects</topic><topic>Ficus - chemistry</topic><topic>Ficus exasperata</topic><topic>furanocoumarin</topic><topic>Furocoumarins - chemistry</topic><topic>Furocoumarins - isolation & purification</topic><topic>Furocoumarins - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Microbial Sensitivity Tests</topic><topic>Microsporum - drug effects</topic><topic>Molecular Structure</topic><topic>Moraceae</topic><topic>Plant Bark - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>sphingolipid</topic><topic>Sphingolipids - chemistry</topic><topic>Sphingolipids - isolation & purification</topic><topic>Sphingolipids - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dongfack, Marlise Diane Jiofack</creatorcontrib><creatorcontrib>Lallemand, Marie-Christine</creatorcontrib><creatorcontrib>Kuete, Victor</creatorcontrib><creatorcontrib>Mbazoa, Céline Djama</creatorcontrib><creatorcontrib>Wansi, Jean-Duplex</creatorcontrib><creatorcontrib>Trinh-van-Dufat, Hanh</creatorcontrib><creatorcontrib>Michel, Sylvie</creatorcontrib><creatorcontrib>Wandji, Jean</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dongfack, Marlise Diane Jiofack</au><au>Lallemand, Marie-Christine</au><au>Kuete, Victor</au><au>Mbazoa, Céline Djama</au><au>Wansi, Jean-Duplex</au><au>Trinh-van-Dufat, Hanh</au><au>Michel, Sylvie</au><au>Wandji, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2012</date><risdate>2012</risdate><volume>60</volume><issue>8</issue><spage>1072</spage><epage>1075</epage><pages>1072-1075</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(－) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>22863713</pmid><doi>10.1248/cpb.c12-00279</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 2012/08/01, Vol.60(8), pp.1072-1075 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1032610670 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | antimicrobial activity Bacillus cereus - drug effects Candida albicans - drug effects Escherichia coli - drug effects Ficus - chemistry Ficus exasperata furanocoumarin Furocoumarins - chemistry Furocoumarins - isolation & purification Furocoumarins - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microsporum - drug effects Molecular Structure Moraceae Plant Bark - chemistry Plant Extracts - pharmacology Spectrometry, Mass, Electrospray Ionization sphingolipid Sphingolipids - chemistry Sphingolipids - isolation & purification Sphingolipids - pharmacology |
| title | A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T14%3A00%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20New%20Sphingolipid%20and%20Furanocoumarins%20with%20Antimicrobial%20Activity%20from%20Ficus%20exasperata&rft.jtitle=Chemical%20&%20pharmaceutical%20bulletin&rft.au=Dongfack,%20Marlise%20Diane%20Jiofack&rft.date=2012&rft.volume=60&rft.issue=8&rft.spage=1072&rft.epage=1075&rft.pages=1072-1075&rft.issn=0009-2363&rft.eissn=1347-5223&rft_id=info:doi/10.1248/cpb.c12-00279&rft_dat=%3Cproquest_cross%3E1032610670%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1460458246&rft_id=info:pmid/22863713&rfr_iscdi=true |