A case of autoimmune pancreatitis with multifocal mass lesions
We present a case of a 73-year-old man with multifocal autoimmune pancreatitis (AIP) in the pancreatic head and tail, and who had undergone sigmoidectomy and rectectomy 28 months before presenting to our department. Upon presentation, his serum IgG4 level was elevated at 267mg/dl, but tumor marker l...
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Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 2012, Vol.109(8), pp.1409-1418 |
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creator | HIRAMATSU, Shinsuke NEBIKI, Hiroko UENO, Ayako MARUYAMA, Hirotsugu SUEKANE, Takehisa YAMASAKI, Tomoaki SASAKI, Eiji SANO, Koji SATO, Hiroshi |
description | We present a case of a 73-year-old man with multifocal autoimmune pancreatitis (AIP) in the pancreatic head and tail, and who had undergone sigmoidectomy and rectectomy 28 months before presenting to our department. Upon presentation, his serum IgG4 level was elevated at 267mg/dl, but tumor marker levels were within normal ranges. CT and MRI showed two localized pancreatic masses with delayed enhancement, but endoscopic retrograde pancreatography revealed neither stenosis nor dilatation of the main pancreatic duct. FDG-PET examination showed intense uptake in regions concordant with both tumors. The possibility of atypical AIP was a concern, but malignant tumor could not be clinically or radiologically excluded. Endoscopic ultrasonographic fine-needle aspiration biopsy was performed, but no malignant cells were detected. The patient underwent subsequent distal pancreatectomy. Histological evaluation of the tumors showed the presence of many IgG4-positive plasma cells without any evidence of malignancy. |
doi_str_mv | 10.11405/nisshoshi.109.1409 |
format | Article |
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Upon presentation, his serum IgG4 level was elevated at 267mg/dl, but tumor marker levels were within normal ranges. CT and MRI showed two localized pancreatic masses with delayed enhancement, but endoscopic retrograde pancreatography revealed neither stenosis nor dilatation of the main pancreatic duct. FDG-PET examination showed intense uptake in regions concordant with both tumors. The possibility of atypical AIP was a concern, but malignant tumor could not be clinically or radiologically excluded. Endoscopic ultrasonographic fine-needle aspiration biopsy was performed, but no malignant cells were detected. The patient underwent subsequent distal pancreatectomy. 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Upon presentation, his serum IgG4 level was elevated at 267mg/dl, but tumor marker levels were within normal ranges. CT and MRI showed two localized pancreatic masses with delayed enhancement, but endoscopic retrograde pancreatography revealed neither stenosis nor dilatation of the main pancreatic duct. FDG-PET examination showed intense uptake in regions concordant with both tumors. The possibility of atypical AIP was a concern, but malignant tumor could not be clinically or radiologically excluded. Endoscopic ultrasonographic fine-needle aspiration biopsy was performed, but no malignant cells were detected. The patient underwent subsequent distal pancreatectomy. Histological evaluation of the tumors showed the presence of many IgG4-positive plasma cells without any evidence of malignancy.</description><subject>Aged</subject><subject>Autoimmune Diseases - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Pancreatitis - pathology</subject><subject>Pancreatitis - surgery</subject><subject>Postoperative Complications</subject><subject>Rectal Neoplasms - surgery</subject><subject>Sigmoid Neoplasms - surgery</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF9LwzAUxYMobsx9AkHy6Etn0vxp8iKM4VQY-KLPJc1Sm9E0szdF_PZ2bu7l3MPlx4FzELqlZEEpJ-Kh8wBNhMYvKNGL8aUv0JQyrrNCanaJpoRzmUmh5ATNAXxFCNFCK8au0STPlWRayil6XGJrwOFYYzOk6EMYOof3prO9M8knD_jbpwaHoU2-jta0OBgA3DrwsYMbdFWbFtz8dGfoY_30vnrJNm_Pr6vlJttRpVMmpSiUUDXNa6YJ23JFWV3ZSrOcC0WLSlEqCylsZSk1fHRcFco6RXKjRU7YDN0fc_d9_BocpDJ4sK5tTefiACUlLJdjP1KM6N0JHargtuW-98H0P-V_5xFYH4EdJPPpzoDpk7etK8_Ljqm6VH962PcM2Mb0pevYL1k7c7Q</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>HIRAMATSU, Shinsuke</creator><creator>NEBIKI, Hiroko</creator><creator>UENO, Ayako</creator><creator>MARUYAMA, Hirotsugu</creator><creator>SUEKANE, Takehisa</creator><creator>YAMASAKI, Tomoaki</creator><creator>SASAKI, Eiji</creator><creator>SANO, Koji</creator><creator>SATO, Hiroshi</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>A case of autoimmune pancreatitis with multifocal mass lesions</title><author>HIRAMATSU, Shinsuke ; NEBIKI, Hiroko ; UENO, Ayako ; MARUYAMA, Hirotsugu ; SUEKANE, Takehisa ; YAMASAKI, Tomoaki ; SASAKI, Eiji ; SANO, Koji ; SATO, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j189t-6657858f12f3903d4813fbcb93245817b8116765cbc11a47654878ce802a95203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Autoimmune Diseases - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Pancreatitis - pathology</topic><topic>Pancreatitis - surgery</topic><topic>Postoperative Complications</topic><topic>Rectal Neoplasms - surgery</topic><topic>Sigmoid Neoplasms - surgery</topic><toplevel>online_resources</toplevel><creatorcontrib>HIRAMATSU, Shinsuke</creatorcontrib><creatorcontrib>NEBIKI, Hiroko</creatorcontrib><creatorcontrib>UENO, Ayako</creatorcontrib><creatorcontrib>MARUYAMA, Hirotsugu</creatorcontrib><creatorcontrib>SUEKANE, Takehisa</creatorcontrib><creatorcontrib>YAMASAKI, Tomoaki</creatorcontrib><creatorcontrib>SASAKI, Eiji</creatorcontrib><creatorcontrib>SANO, Koji</creatorcontrib><creatorcontrib>SATO, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRAMATSU, Shinsuke</au><au>NEBIKI, Hiroko</au><au>UENO, Ayako</au><au>MARUYAMA, Hirotsugu</au><au>SUEKANE, Takehisa</au><au>YAMASAKI, Tomoaki</au><au>SASAKI, Eiji</au><au>SANO, Koji</au><au>SATO, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of autoimmune pancreatitis with multifocal mass lesions</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>2012-08</date><risdate>2012</risdate><volume>109</volume><issue>8</issue><spage>1409</spage><epage>1418</epage><pages>1409-1418</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>We present a case of a 73-year-old man with multifocal autoimmune pancreatitis (AIP) in the pancreatic head and tail, and who had undergone sigmoidectomy and rectectomy 28 months before presenting to our department. Upon presentation, his serum IgG4 level was elevated at 267mg/dl, but tumor marker levels were within normal ranges. CT and MRI showed two localized pancreatic masses with delayed enhancement, but endoscopic retrograde pancreatography revealed neither stenosis nor dilatation of the main pancreatic duct. FDG-PET examination showed intense uptake in regions concordant with both tumors. The possibility of atypical AIP was a concern, but malignant tumor could not be clinically or radiologically excluded. Endoscopic ultrasonographic fine-needle aspiration biopsy was performed, but no malignant cells were detected. The patient underwent subsequent distal pancreatectomy. Histological evaluation of the tumors showed the presence of many IgG4-positive plasma cells without any evidence of malignancy.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>22863966</pmid><doi>10.11405/nisshoshi.109.1409</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Autoimmune Diseases - pathology Humans Male Pancreatitis - pathology Pancreatitis - surgery Postoperative Complications Rectal Neoplasms - surgery Sigmoid Neoplasms - surgery |
title | A case of autoimmune pancreatitis with multifocal mass lesions |
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