Clionosterol and Ethyl Cholestan-22-enol Isolated from the Rhizome of Polygala tenuifolia Inhibit Phosphatidylinositol 3-Kinase/Akt Pathway

Phosphatidylinositol 3-kinase (PI3K)/Akt inhibitors were isolated from the rhizome of Polygala tenuifolia WILLD (PT, Polygalaceae), which has been used in traditional Chinese medicine for inflammation, dementia, amnesia, neurasthenia and cancer, by activity-guided fractionation. For the assay of PI3...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2012/08/01, Vol.35(8), pp.1379-1383
Hauptverfasser:	Le, Thi Kim Van, Jeong, Jin Ju, Kim, Dong-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line cell survival pathway inhibitor Cholestanols - isolation & purification Cholestanols - pharmacology Cycloheximide Cytoprotection - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Gene Products, tat - metabolism Humans Lipopolysaccharides macrophage Phosphatidylinositol 3-Kinase - antagonists & inhibitors Plant Extracts - chemistry Plant Extracts - pharmacology Polygala - chemistry Polygala tenuifolia Proto-Oncogene Proteins c-akt - antagonists & inhibitors Rhizome - chemistry Signal Transduction - drug effects Sitosterols - isolation & purification Sitosterols - pharmacology Viral Proteins - metabolism
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