The burden of hospitalization related to diabetes mellitus: A population-based study
Abstract Background and aims To estimate the impact of diabetes and its complications, overall and in different age classes, on the likelihood of hospital admission for specific causes. Methods and results We carried out a record-linkage analysis of administrative registers including data on 8,940,4...
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| creator | De Berardis, G D’Ettorre, A Graziano, G Lucisano, G Pellegrini, F Cammarota, S Citarella, A Germinario, C.A Lepore, V Menditto, E Nicolosi, A Vitullo, F Nicolucci, A |
| description | Abstract Background and aims To estimate the impact of diabetes and its complications, overall and in different age classes, on the likelihood of hospital admission for specific causes. Methods and results We carried out a record-linkage analysis of administrative registers including data on 8,940,420 citizens in 21 Local Health Authorities in Italy. Individuals with pharmacologically treated diabetes (≥2 prescriptions of antidiabetic agents during the year 2008) were paired in a 1:1 proportion with those who did not receive such drugs (controls) based on propensity-score matching. Odds Ratios (ORs) of hospitalization for macro and microvascular conditions in individuals with diabetes as compared to controls were estimated. The system identified 498,825 individuals with diabetes pharmacologically treated (prevalence of 5.6%). Prevalence of diabetes in people aged |
| doi_str_mv | 10.1016/j.numecd.2010.10.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1032608393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0939475310002516</els_id><sourcerecordid>1032608393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-e49e858b6728dbc65a15bcbf9f8d1d29d5c1997383e4d9860a258ae1431a79023</originalsourceid><addsrcrecordid>eNqFkUtv1TAQhS0EoreFf4AgSza5-BEnNgukqoKCVIlFb9eWY0-oL0kc_EC6_HqcprBgw2qko2_OHJ1B6BXBe4JJ--64n_MExu4pfpD2RXyCdoRLXLOOyqdohyWTddNxdobOYzxizDrMmufojBLGGMdihw6He6j6HCzMlR-qex8Xl_Tofunk_FwFGHUCWyVfWad7SBCrCcbRpRzfV5fV4pc8PqB1r2MBY8r29AI9G_QY4eXjvEB3nz4erj7XN1-vv1xd3tSmaUiqoZEguOjbjgrbm5ZrwnvTD3IQllgqLTdEyo4JBo2VosWacqGBNIzoTmLKLtDbzXcJ_keGmNTkoinx9Aw-R0Uwoy0WTLKCNhtqgo8xwKCW4CYdTgVSa5_qqLY-1drnqhaxrL1-vJD7CezfpT8FFuDNBgzaK_0tuKjubosDxxgL0so15IeNgNLETwdBReNgNmBdAJOU9e5_Gf41MKObndHjdzhBPPoc5tKyIipShdXt-vX16aREoLwY_AbK96Yw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1032608393</pqid></control><display><type>article</type><title>The burden of hospitalization related to diabetes mellitus: A population-based study</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>De Berardis, G ; D’Ettorre, A ; Graziano, G ; Lucisano, G ; Pellegrini, F ; Cammarota, S ; Citarella, A ; Germinario, C.A ; Lepore, V ; Menditto, E ; Nicolosi, A ; Vitullo, F ; Nicolucci, A</creator><creatorcontrib>De Berardis, G ; D’Ettorre, A ; Graziano, G ; Lucisano, G ; Pellegrini, F ; Cammarota, S ; Citarella, A ; Germinario, C.A ; Lepore, V ; Menditto, E ; Nicolosi, A ; Vitullo, F ; Nicolucci, A ; for the DADA (Diabetes Administrative Data Analysis) Study Group ; DADA (Diabetes Administrative Data Analysis) Study Group</creatorcontrib><description>Abstract Background and aims To estimate the impact of diabetes and its complications, overall and in different age classes, on the likelihood of hospital admission for specific causes. Methods and results We carried out a record-linkage analysis of administrative registers including data on 8,940,420 citizens in 21 Local Health Authorities in Italy. Individuals with pharmacologically treated diabetes (≥2 prescriptions of antidiabetic agents during the year 2008) were paired in a 1:1 proportion with those who did not receive such drugs (controls) based on propensity-score matching. Odds Ratios (ORs) of hospitalization for macro and microvascular conditions in individuals with diabetes as compared to controls were estimated. The system identified 498,825 individuals with diabetes pharmacologically treated (prevalence of 5.6%). Prevalence of diabetes in people aged <14 years, 14–39 years, 40–65 years, and ≥65 years was 0.1%, 0.6%, 6.4%, and 18.2%, respectively. Overall, 23.9% of subjects with diabetes and 11.5% of controls had had at least a hospital admission during 12 months for the causes considered. Diabetes increased the likelihood of hospitalization by two to six times for the different causes examined. In absolute terms, diabetes was responsible for an excess of over 12,000 hospital admissions per 100,000 individuals/year. Conclusion Despite the availability of effective treatments to prevent or delay major complications, diabetes still places an enormous burden on both patients and the health care system. Given the continuous rise in diabetes prevalence both in middle-aged and elderly individuals, we can expect an additional, hardly sustainable increase in the demand for health care in the near future.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2010.10.016</identifier><identifier>PMID: 21333508</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administrative data ; Adolescent ; Adult ; age structure ; Aged ; Benzamides - therapeutic use ; Cardiovascular ; Cost of Illness ; Diabetes ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - epidemiology ; diabetic complications ; elderly ; Epidemiology ; Female ; health services ; Hospitalization ; Humans ; hypoglycemic agents ; Hypoglycemic Agents - therapeutic use ; Insulin - therapeutic use ; Italy - epidemiology ; Male ; Metformin - therapeutic use ; Middle Aged ; middle-aged adults ; Odds Ratio ; patients ; Prevalence ; Thiazolidinediones - therapeutic use ; Treatment Outcome ; Young Adult</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2012-07, Vol.22 (7), p.605-612</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e49e858b6728dbc65a15bcbf9f8d1d29d5c1997383e4d9860a258ae1431a79023</citedby><cites>FETCH-LOGICAL-c441t-e49e858b6728dbc65a15bcbf9f8d1d29d5c1997383e4d9860a258ae1431a79023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.numecd.2010.10.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21333508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Berardis, G</creatorcontrib><creatorcontrib>D’Ettorre, A</creatorcontrib><creatorcontrib>Graziano, G</creatorcontrib><creatorcontrib>Lucisano, G</creatorcontrib><creatorcontrib>Pellegrini, F</creatorcontrib><creatorcontrib>Cammarota, S</creatorcontrib><creatorcontrib>Citarella, A</creatorcontrib><creatorcontrib>Germinario, C.A</creatorcontrib><creatorcontrib>Lepore, V</creatorcontrib><creatorcontrib>Menditto, E</creatorcontrib><creatorcontrib>Nicolosi, A</creatorcontrib><creatorcontrib>Vitullo, F</creatorcontrib><creatorcontrib>Nicolucci, A</creatorcontrib><creatorcontrib>for the DADA (Diabetes Administrative Data Analysis) Study Group</creatorcontrib><creatorcontrib>DADA (Diabetes Administrative Data Analysis) Study Group</creatorcontrib><title>The burden of hospitalization related to diabetes mellitus: A population-based study</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims To estimate the impact of diabetes and its complications, overall and in different age classes, on the likelihood of hospital admission for specific causes. Methods and results We carried out a record-linkage analysis of administrative registers including data on 8,940,420 citizens in 21 Local Health Authorities in Italy. Individuals with pharmacologically treated diabetes (≥2 prescriptions of antidiabetic agents during the year 2008) were paired in a 1:1 proportion with those who did not receive such drugs (controls) based on propensity-score matching. Odds Ratios (ORs) of hospitalization for macro and microvascular conditions in individuals with diabetes as compared to controls were estimated. The system identified 498,825 individuals with diabetes pharmacologically treated (prevalence of 5.6%). Prevalence of diabetes in people aged <14 years, 14–39 years, 40–65 years, and ≥65 years was 0.1%, 0.6%, 6.4%, and 18.2%, respectively. Overall, 23.9% of subjects with diabetes and 11.5% of controls had had at least a hospital admission during 12 months for the causes considered. Diabetes increased the likelihood of hospitalization by two to six times for the different causes examined. In absolute terms, diabetes was responsible for an excess of over 12,000 hospital admissions per 100,000 individuals/year. Conclusion Despite the availability of effective treatments to prevent or delay major complications, diabetes still places an enormous burden on both patients and the health care system. Given the continuous rise in diabetes prevalence both in middle-aged and elderly individuals, we can expect an additional, hardly sustainable increase in the demand for health care in the near future.</description><subject>Administrative data</subject><subject>Adolescent</subject><subject>Adult</subject><subject>age structure</subject><subject>Aged</subject><subject>Benzamides - therapeutic use</subject><subject>Cardiovascular</subject><subject>Cost of Illness</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>diabetic complications</subject><subject>elderly</subject><subject>Epidemiology</subject><subject>Female</subject><subject>health services</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>hypoglycemic agents</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - therapeutic use</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Metformin - therapeutic use</subject><subject>Middle Aged</subject><subject>middle-aged adults</subject><subject>Odds Ratio</subject><subject>patients</subject><subject>Prevalence</subject><subject>Thiazolidinediones - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EoreFf4AgSza5-BEnNgukqoKCVIlFb9eWY0-oL0kc_EC6_HqcprBgw2qko2_OHJ1B6BXBe4JJ--64n_MExu4pfpD2RXyCdoRLXLOOyqdohyWTddNxdobOYzxizDrMmufojBLGGMdihw6He6j6HCzMlR-qex8Xl_Tofunk_FwFGHUCWyVfWad7SBCrCcbRpRzfV5fV4pc8PqB1r2MBY8r29AI9G_QY4eXjvEB3nz4erj7XN1-vv1xd3tSmaUiqoZEguOjbjgrbm5ZrwnvTD3IQllgqLTdEyo4JBo2VosWacqGBNIzoTmLKLtDbzXcJ_keGmNTkoinx9Aw-R0Uwoy0WTLKCNhtqgo8xwKCW4CYdTgVSa5_qqLY-1drnqhaxrL1-vJD7CezfpT8FFuDNBgzaK_0tuKjubosDxxgL0so15IeNgNLETwdBReNgNmBdAJOU9e5_Gf41MKObndHjdzhBPPoc5tKyIipShdXt-vX16aREoLwY_AbK96Yw</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>De Berardis, G</creator><creator>D’Ettorre, A</creator><creator>Graziano, G</creator><creator>Lucisano, G</creator><creator>Pellegrini, F</creator><creator>Cammarota, S</creator><creator>Citarella, A</creator><creator>Germinario, C.A</creator><creator>Lepore, V</creator><creator>Menditto, E</creator><creator>Nicolosi, A</creator><creator>Vitullo, F</creator><creator>Nicolucci, A</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>The burden of hospitalization related to diabetes mellitus: A population-based study</title><author>De Berardis, G ; D’Ettorre, A ; Graziano, G ; Lucisano, G ; Pellegrini, F ; Cammarota, S ; Citarella, A ; Germinario, C.A ; Lepore, V ; Menditto, E ; Nicolosi, A ; Vitullo, F ; Nicolucci, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e49e858b6728dbc65a15bcbf9f8d1d29d5c1997383e4d9860a258ae1431a79023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administrative data</topic><topic>Adolescent</topic><topic>Adult</topic><topic>age structure</topic><topic>Aged</topic><topic>Benzamides - therapeutic use</topic><topic>Cardiovascular</topic><topic>Cost of Illness</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>diabetic complications</topic><topic>elderly</topic><topic>Epidemiology</topic><topic>Female</topic><topic>health services</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>hypoglycemic agents</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - therapeutic use</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Metformin - therapeutic use</topic><topic>Middle Aged</topic><topic>middle-aged adults</topic><topic>Odds Ratio</topic><topic>patients</topic><topic>Prevalence</topic><topic>Thiazolidinediones - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Berardis, G</creatorcontrib><creatorcontrib>D’Ettorre, A</creatorcontrib><creatorcontrib>Graziano, G</creatorcontrib><creatorcontrib>Lucisano, G</creatorcontrib><creatorcontrib>Pellegrini, F</creatorcontrib><creatorcontrib>Cammarota, S</creatorcontrib><creatorcontrib>Citarella, A</creatorcontrib><creatorcontrib>Germinario, C.A</creatorcontrib><creatorcontrib>Lepore, V</creatorcontrib><creatorcontrib>Menditto, E</creatorcontrib><creatorcontrib>Nicolosi, A</creatorcontrib><creatorcontrib>Vitullo, F</creatorcontrib><creatorcontrib>Nicolucci, A</creatorcontrib><creatorcontrib>for the DADA (Diabetes Administrative Data Analysis) Study Group</creatorcontrib><creatorcontrib>DADA (Diabetes Administrative Data Analysis) Study Group</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Berardis, G</au><au>D’Ettorre, A</au><au>Graziano, G</au><au>Lucisano, G</au><au>Pellegrini, F</au><au>Cammarota, S</au><au>Citarella, A</au><au>Germinario, C.A</au><au>Lepore, V</au><au>Menditto, E</au><au>Nicolosi, A</au><au>Vitullo, F</au><au>Nicolucci, A</au><aucorp>for the DADA (Diabetes Administrative Data Analysis) Study Group</aucorp><aucorp>DADA (Diabetes Administrative Data Analysis) Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The burden of hospitalization related to diabetes mellitus: A population-based study</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>22</volume><issue>7</issue><spage>605</spage><epage>612</epage><pages>605-612</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aims To estimate the impact of diabetes and its complications, overall and in different age classes, on the likelihood of hospital admission for specific causes. Methods and results We carried out a record-linkage analysis of administrative registers including data on 8,940,420 citizens in 21 Local Health Authorities in Italy. Individuals with pharmacologically treated diabetes (≥2 prescriptions of antidiabetic agents during the year 2008) were paired in a 1:1 proportion with those who did not receive such drugs (controls) based on propensity-score matching. Odds Ratios (ORs) of hospitalization for macro and microvascular conditions in individuals with diabetes as compared to controls were estimated. The system identified 498,825 individuals with diabetes pharmacologically treated (prevalence of 5.6%). Prevalence of diabetes in people aged <14 years, 14–39 years, 40–65 years, and ≥65 years was 0.1%, 0.6%, 6.4%, and 18.2%, respectively. Overall, 23.9% of subjects with diabetes and 11.5% of controls had had at least a hospital admission during 12 months for the causes considered. Diabetes increased the likelihood of hospitalization by two to six times for the different causes examined. In absolute terms, diabetes was responsible for an excess of over 12,000 hospital admissions per 100,000 individuals/year. Conclusion Despite the availability of effective treatments to prevent or delay major complications, diabetes still places an enormous burden on both patients and the health care system. Given the continuous rise in diabetes prevalence both in middle-aged and elderly individuals, we can expect an additional, hardly sustainable increase in the demand for health care in the near future.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21333508</pmid><doi>10.1016/j.numecd.2010.10.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Administrative data Adolescent Adult age structure Aged Benzamides - therapeutic use Cardiovascular Cost of Illness Diabetes Diabetes Mellitus - drug therapy Diabetes Mellitus - epidemiology diabetic complications elderly Epidemiology Female health services Hospitalization Humans hypoglycemic agents Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Italy - epidemiology Male Metformin - therapeutic use Middle Aged middle-aged adults Odds Ratio patients Prevalence Thiazolidinediones - therapeutic use Treatment Outcome Young Adult |
| title | The burden of hospitalization related to diabetes mellitus: A population-based study |
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