The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns
Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence end...
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| Veröffentlicht in: | Collegium antropologicum 2012-06, Vol.36 (2), p.395-400 |
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| container_title | Collegium antropologicum |
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| creator | Sarunić, Alenka Vukelić Cvijanović, Olga Dudarić, Luka Denona, Branko Vukelić, Lucian Bobinac, Dragica Finderle, Aleks |
| description | Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia. |
| format | Article |
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Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. 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Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.</description><subject>Adult</subject><subject>Anthropometry</subject><subject>Apgar Score</subject><subject>Asphyxia Neonatorum - blood</subject><subject>Asphyxia Neonatorum - epidemiology</subject><subject>Endothelin-1 - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - blood</subject><subject>Hypertension, Pregnancy-Induced - epidemiology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><issn>0350-6134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPxDAQhF2AuOPgLyCXNJH8iPMo0YmXdBLNUUeOveaMHDvYCSd6fjgOHMVqVrMzX7FnaE24IEVFeblClym9EyLqilQXaMVYIyrG6Bp97w-ArTduBq8AB4OVs94q6bD0Os90iGEMA0zRKjzKKPMKMeHg8ZSrCeI8YAef4NLSXjzwOmTNnIJmNh4jvPlMwsfM8b_cfLYRezj2Ifp0hc6NdAmuT7pBrw_3--1TsXt5fN7e7YqRUToVvFG91LKGVoNhlGsNRHFtSl1XgpZcy5JzoQ1pmBFt3ytlWg6GQ0MlF23NN-j2jzvG8DFDmrrBJgXOSQ9hTh0lnNKKCLpEb07RuR9Ad2O0g4xf3f_n-A8l6WxY</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Sarunić, Alenka Vukelić</creator><creator>Cvijanović, Olga</creator><creator>Dudarić, Luka</creator><creator>Denona, Branko</creator><creator>Vukelić, Lucian</creator><creator>Bobinac, Dragica</creator><creator>Finderle, Aleks</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns</title><author>Sarunić, Alenka Vukelić ; Cvijanović, Olga ; Dudarić, Luka ; Denona, Branko ; Vukelić, Lucian ; Bobinac, Dragica ; Finderle, Aleks</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-38cbada7e9def213dde0c3df4d765143da4335df082f59bbccf93ef3e81a35973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Anthropometry</topic><topic>Apgar Score</topic><topic>Asphyxia Neonatorum - blood</topic><topic>Asphyxia Neonatorum - epidemiology</topic><topic>Endothelin-1 - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - blood</topic><topic>Hypertension, Pregnancy-Induced - epidemiology</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarunić, Alenka Vukelić</creatorcontrib><creatorcontrib>Cvijanović, Olga</creatorcontrib><creatorcontrib>Dudarić, Luka</creatorcontrib><creatorcontrib>Denona, Branko</creatorcontrib><creatorcontrib>Vukelić, Lucian</creatorcontrib><creatorcontrib>Bobinac, Dragica</creatorcontrib><creatorcontrib>Finderle, Aleks</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Collegium antropologicum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarunić, Alenka Vukelić</au><au>Cvijanović, Olga</au><au>Dudarić, Luka</au><au>Denona, Branko</au><au>Vukelić, Lucian</au><au>Bobinac, Dragica</au><au>Finderle, Aleks</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns</atitle><jtitle>Collegium antropologicum</jtitle><addtitle>Coll Antropol</addtitle><date>2012-06</date><risdate>2012</risdate><volume>36</volume><issue>2</issue><spage>395</spage><epage>400</epage><pages>395-400</pages><issn>0350-6134</issn><abstract>Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.</abstract><cop>Croatia</cop><pmid>22856221</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Collegium antropologicum, 2012-06, Vol.36 (2), p.395-400 |
| issn | 0350-6134 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Anthropometry Apgar Score Asphyxia Neonatorum - blood Asphyxia Neonatorum - epidemiology Endothelin-1 - blood Female Humans Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - epidemiology Infant, Newborn Male Pregnancy Risk Factors |
| title | The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns |
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