Two-Year Carcinogenicity Studies With the Oral Direct Thrombin Inhibitor Ximelagatran in the Rat and the Mouse

The results of 18 months mouse and 24 months rat carcinogenicity studies with the oral direct thrombin inhibitor ximelagatran are presented. In the mouse, gavage doses of ximelagatran up to 180 μmol/kg per d produced no neoplastic changes in any of the tissues examined. In the rat, gavage doses up t...

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