PTEN deletion is rare but often homogeneous in gastric cancer

Background and aim Gastric carcinoma is the second most frequent cause of cancer-related death worldwide. As PTEN is a potential modifier of tumour response to trastuzumab, a recently approved therapy in metastatic HER2 positive gastric cancer, the existence of PTEN deletions in primary gastric canc...

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Veröffentlicht in:	Journal of clinical pathology 2012-08, Vol.65 (8), p.693-698
Hauptverfasser:	Mina, Sormeh, Bohn, Benjamin A, Simon, Ronald, Krohn, Antje, Reeh, Matthias, Arnold, Dirk, Bokemeyer, Carsten, Sauter, Guido, Izbicki, Jakob R, Marx, Andreas, Stahl, Phillip R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - secondary Aged Artificial chromosomes Biological and medical sciences Biomarkers, Tumor - genetics Breast cancer cancer cancer research Cancer therapies carcinoma Cell growth Chemotherapy Chi-Square Distribution Female fish fluorescence Gastric cancer gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Gene Deletion Genetic Predisposition to Disease Germany gut pathology Hemizygote Homozygote human Humans Immunohistochemistry in Situ hybridisation In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Kinases Male Medical sciences Metastasis microarray analysis Middle Aged Mortality Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Predictive Value of Tests Prognosis PTEN Phosphohydrolase - genetics PTEN protein Receptor, ErbB-2 - analysis Risk Assessment Risk Factors stomach neoplasms Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies Thoracic surgery Time Factors Tissue Array Analysis - methods Tumors
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