Postexposure chickenpox prophylaxis in children with leukaemia: a reply to the recent PEPtalk study and report of a service evaluation in a tertiary paediatric haematology centre in the UK
The impact of varicella zoster virus (VZV) exposure and disease among our patients, as well as implications on use of hospital resources, may therefore have been significantly underestimated by Bate and his group. Comparison of these rates of clinical disease following acyclovir prophylaxis are simi...
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| Veröffentlicht in: | Archives of disease in childhood 2012-08, Vol.97 (8), p.759-760 |
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| creator | Samuelson, Clare V Rambani, Reena Vora, Ajay J |
| description | The impact of varicella zoster virus (VZV) exposure and disease among our patients, as well as implications on use of hospital resources, may therefore have been significantly underestimated by Bate and his group. Comparison of these rates of clinical disease following acyclovir prophylaxis are similar to those reported following VZIG (22% vs 21% respectively), with severe and even fatal cases reported following the use of both forms of prophylaxis. 2 It is our understanding (further supported by the PEPtalk study) that there is no available evidence for inferiority of acyclovir compared with VZIG for PEP of chickenpox in immunocompromised children. |
| doi_str_mv | 10.1136/archdischild-2011-301496 |
| format | Article |
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Comparison of these rates of clinical disease following acyclovir prophylaxis are similar to those reported following VZIG (22% vs 21% respectively), with severe and even fatal cases reported following the use of both forms of prophylaxis. 2 It is our understanding (further supported by the PEPtalk study) that there is no available evidence for inferiority of acyclovir compared with VZIG for PEP of chickenpox in immunocompromised children.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2011-301496</identifier><identifier>PMID: 22523432</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Care and treatment ; Chicken pox ; Chickenpox ; Chickenpox - prevention & control ; Children ; Data Collection ; Diseases ; Drug therapy ; Evidence ; Health aspects ; Hematology ; Humans ; Immune Sera - administration & dosage ; Leukemia ; Literature Reviews ; Mortality ; Neoplasms - complications ; Opportunistic Infections - prevention & control ; Patients ; Pediatric diseases ; Post-Exposure Prophylaxis - methods ; Prophylaxis ; Records (Forms)</subject><ispartof>Archives of disease in childhood, 2012-08, Vol.97 (8), p.759-760</ispartof><rights>Published by the BMJ Publishing Group Limited. 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Comparison of these rates of clinical disease following acyclovir prophylaxis are similar to those reported following VZIG (22% vs 21% respectively), with severe and even fatal cases reported following the use of both forms of prophylaxis. 2 It is our understanding (further supported by the PEPtalk study) that there is no available evidence for inferiority of acyclovir compared with VZIG for PEP of chickenpox in immunocompromised children.</description><subject>Care and treatment</subject><subject>Chicken pox</subject><subject>Chickenpox</subject><subject>Chickenpox - prevention & control</subject><subject>Children</subject><subject>Data Collection</subject><subject>Diseases</subject><subject>Drug therapy</subject><subject>Evidence</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immune Sera - administration & dosage</subject><subject>Leukemia</subject><subject>Literature Reviews</subject><subject>Mortality</subject><subject>Neoplasms - complications</subject><subject>Opportunistic Infections - prevention & control</subject><subject>Patients</subject><subject>Pediatric diseases</subject><subject>Post-Exposure Prophylaxis - methods</subject><subject>Prophylaxis</subject><subject>Records (Forms)</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNklFv0zAUhSMEYmXwF5AlXngJ2HHquLxN1QaIaeukjVfrJrlu3LpxsJ3R_jd-HA4dA_GE8mAl-e49R8cnywij7xjj4j34pmtNaDpj27ygjOWcsnIhnmQzVgqZPpXl02xGKeX5Qkp5kr0IYUMpK6Tkz7OTopgXvOTFLPuxciHifnBh9EjSwmaL_eD2ZPBu6A4W9iYQ05NfUh578t3Ejlgct4A7Ax8IEI-DPZDoSOwwvTTYR7I6X0WwWxLi2B4I9O1EOR-J02kioL83DRK8BztCNK6fJIBE9NGAP5ABsDUQvWlIl3QgOuvWBzKtTi4TO0ndfXmZPdNgA756OE-zu4vz2-Wn_PL64-fl2WVel4LHXLYCtC6oRlFJLmpOAUrOsF3otuaymnOhm2ahNUUNopAF0rksa76gwNg8JXWavT3uTaF8GzFEtUvho7XQoxuDYpQnUKQ9CX3zD7pxo--TO8VkSr-kTJSJyo_UGiwq0zeuT5cQG2ctrlEl88trdcZpeljFpq3yyDfeheBRq8GbXUoqSaupEervRqipEerYiDT6-sHQWO-wfRz8XYE_XsxUhMf_4LdKVLyaq6uvS3WzlLfFzepKVYnnR77ebf7fxk_eKdgf</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Samuelson, Clare V</creator><creator>Rambani, Reena</creator><creator>Vora, Ajay J</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Postexposure chickenpox prophylaxis in children with leukaemia: a reply to the recent PEPtalk study and report of a service evaluation in a tertiary paediatric haematology centre in the UK</title><author>Samuelson, Clare V ; 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| language | eng |
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| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Care and treatment Chicken pox Chickenpox Chickenpox - prevention & control Children Data Collection Diseases Drug therapy Evidence Health aspects Hematology Humans Immune Sera - administration & dosage Leukemia Literature Reviews Mortality Neoplasms - complications Opportunistic Infections - prevention & control Patients Pediatric diseases Post-Exposure Prophylaxis - methods Prophylaxis Records (Forms) |
| title | Postexposure chickenpox prophylaxis in children with leukaemia: a reply to the recent PEPtalk study and report of a service evaluation in a tertiary paediatric haematology centre in the UK |
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