Joint Effects of Genetic Variants in Multiple Loci on the Risk of Coronary Artery Disease in Chinese Han Subjects

Background: The aim of the present study was to explore risk variants for coronary artery disease (CAD) and to evaluate their joint effects (quantified by genetic risk score; GRS) on the discrimination of CAD in a Chinese Han sample. Methods and Results: An association analysis of 91 single nucleoti...

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Veröffentlicht in:	Circulation Journal 2012, Vol.76(8), pp.1987-1992
Hauptverfasser:	Lv, Xiaofei, Zhang, Yuan, Rao, Shaoqi, Qiu, Jian, Wang, Min, Luo, Xiaoqin, Zuo, Xiaoyu, Su, Dongfang, Feng, Xiang, Yang, Yan, Ouyang, Ping, Chen, Yibing, Li, Xinrui, Xiao, Yunjun, Ling, Wenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asian Continental Ancestry Group China - epidemiology Coronary artery disease Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Female Genetic Loci Genetic risk score Genetic variants Humans Joint effect Male Middle Aged Multifactorial Inheritance Polymorphism, Single Nucleotide Risk Factors ROC Curve
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