Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction
The aim of this study was to evaluate the glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction (ED). We evaluated 88 type 2 diabetic males, aged 62.78±9.26 years. We administered patients the IIEF (International Index of Erectile Function) questionnaire to assess erectile...
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| Veröffentlicht in: | Endocrine Journal 2012, Vol.59(7), pp.611-619 |
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| creator | Derosa, Giuseppe Tinelli, Carmine D’Angelo, Angela Ferrara, Gianluca Bonaventura, Aldo Bianchi, Lucio Romano, Davide Fogari, Elena Maffioli, Pamela |
| description | The aim of this study was to evaluate the glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction (ED). We evaluated 88 type 2 diabetic males, aged 62.78±9.26 years. We administered patients the IIEF (International Index of Erectile Function) questionnaire to assess erectile function, organ function, sexual desire, and satisfaction level during and after the sexual intercourse and the SAS (self-rating anxiety scale) and SDS (self-rating depression scale) questionnaires to evaluate anxiety and depression. We evaluated: BMI, abdominal circumference, glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA index, lipid profile, testosterone, free testosterone, dihydrotestosterone, and sex hormone binding globulin (SHBG). The IIEF questionnaire showed that in the examined sample there were 50 patients (56.8%) affected by ED, and 38 patients (43.2%) without ED. Comparing the two groups, 57.9% of patients without ED, and 70.0% of patients with ED were smokers, and the difference between the two groups was significant (p |
| doi_str_mv | 10.1507/endocrj.EJ12-0117 |
| format | Article |
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We evaluated 88 type 2 diabetic males, aged 62.78±9.26 years. We administered patients the IIEF (International Index of Erectile Function) questionnaire to assess erectile function, organ function, sexual desire, and satisfaction level during and after the sexual intercourse and the SAS (self-rating anxiety scale) and SDS (self-rating depression scale) questionnaires to evaluate anxiety and depression. We evaluated: BMI, abdominal circumference, glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA index, lipid profile, testosterone, free testosterone, dihydrotestosterone, and sex hormone binding globulin (SHBG). The IIEF questionnaire showed that in the examined sample there were 50 patients (56.8%) affected by ED, and 38 patients (43.2%) without ED. Comparing the two groups, 57.9% of patients without ED, and 70.0% of patients with ED were smokers, and the difference between the two groups was significant (p<0.05). Furthermore, 23.7% of patients without ED, and 38.0% of patients with ED had a history of chronic ischemic heart disease (p<0.05 between the two groups). Patients with ED were older, and, surprisingly, had lower levels of HbA1c. Furthermore, patients with ED had higher levels of FPI, and lower levels of testosterone and dihydrotestosterone. The prevalence of ED in Italian type 2 diabetic males with mean age of 62 years is about 56% and it is linked to higher levels of FPI, but lower levels of HbA1c, free testosterone and dihydrotestosterone.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ12-0117</identifier><identifier>PMID: 22572549</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Aged ; Anxiety - complications ; Anxiety - diagnosis ; Anxiety - epidemiology ; Blood Glucose - metabolism ; Case-Control Studies ; Clinical Trials as Topic ; Depression - complications ; Depression - diagnosis ; Depression - epidemiology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetic Angiopathies - blood ; Diabetic Angiopathies - metabolism ; Erectile dysfunction ; Erectile Dysfunction - blood ; Erectile Dysfunction - complications ; Erectile Dysfunction - metabolism ; Glycated Hemoglobin A - analysis ; Glycated Hemoglobin A - metabolism ; Humans ; Hyperinsulinemia ; International Index of Erectile Function (IIEF) ; Male ; Metabolome - physiology ; Middle Aged ; Self-Assessment ; Surveys and Questionnaires ; Testosterone ; Testosterone - blood ; Type 2 diabetes mellitus</subject><ispartof>Endocrine Journal, 2012, Vol.59(7), pp.611-619</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-facdb62c6da12f13d4f5bd9e5564cbbacc6835aea1a46c37d7d560ccf2e88b293</citedby><cites>FETCH-LOGICAL-c498t-facdb62c6da12f13d4f5bd9e5564cbbacc6835aea1a46c37d7d560ccf2e88b293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22572549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Derosa, Giuseppe</creatorcontrib><creatorcontrib>Tinelli, Carmine</creatorcontrib><creatorcontrib>D’Angelo, Angela</creatorcontrib><creatorcontrib>Ferrara, Gianluca</creatorcontrib><creatorcontrib>Bonaventura, Aldo</creatorcontrib><creatorcontrib>Bianchi, Lucio</creatorcontrib><creatorcontrib>Romano, Davide</creatorcontrib><creatorcontrib>Fogari, Elena</creatorcontrib><creatorcontrib>Maffioli, Pamela</creatorcontrib><title>Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction</title><title>Endocrine Journal</title><addtitle>Endocr J</addtitle><description>The aim of this study was to evaluate the glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction (ED). We evaluated 88 type 2 diabetic males, aged 62.78±9.26 years. We administered patients the IIEF (International Index of Erectile Function) questionnaire to assess erectile function, organ function, sexual desire, and satisfaction level during and after the sexual intercourse and the SAS (self-rating anxiety scale) and SDS (self-rating depression scale) questionnaires to evaluate anxiety and depression. We evaluated: BMI, abdominal circumference, glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA index, lipid profile, testosterone, free testosterone, dihydrotestosterone, and sex hormone binding globulin (SHBG). The IIEF questionnaire showed that in the examined sample there were 50 patients (56.8%) affected by ED, and 38 patients (43.2%) without ED. Comparing the two groups, 57.9% of patients without ED, and 70.0% of patients with ED were smokers, and the difference between the two groups was significant (p<0.05). Furthermore, 23.7% of patients without ED, and 38.0% of patients with ED had a history of chronic ischemic heart disease (p<0.05 between the two groups). Patients with ED were older, and, surprisingly, had lower levels of HbA1c. Furthermore, patients with ED had higher levels of FPI, and lower levels of testosterone and dihydrotestosterone. The prevalence of ED in Italian type 2 diabetic males with mean age of 62 years is about 56% and it is linked to higher levels of FPI, but lower levels of HbA1c, free testosterone and dihydrotestosterone.</description><subject>Aged</subject><subject>Anxiety - complications</subject><subject>Anxiety - diagnosis</subject><subject>Anxiety - epidemiology</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Clinical Trials as Topic</subject><subject>Depression - complications</subject><subject>Depression - diagnosis</subject><subject>Depression - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetic Angiopathies - blood</subject><subject>Diabetic Angiopathies - metabolism</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - blood</subject><subject>Erectile Dysfunction - complications</subject><subject>Erectile Dysfunction - metabolism</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hyperinsulinemia</subject><subject>International Index of Erectile Function (IIEF)</subject><subject>Male</subject><subject>Metabolome - physiology</subject><subject>Middle Aged</subject><subject>Self-Assessment</subject><subject>Surveys and Questionnaires</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Type 2 diabetes mellitus</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRbK3-AC-So5fU_UyyRym1KgU96DlsdmfblHzU3Q2Sf29Cay4zA_PMy_AgdE_wkgicPkFjWu0Oy_U7oTEmJL1Ac8J4FnPB8SWaY0myOJNCztCN9weMGROcXaMZpSKlgss5-txUvW7jGoIq2qrU0dG1tqwgUnXb7KLQHyGikSlVAWHcqlBCE3z0W4Z9BA50GGHTe9s1w9w2t-jKqsrD3bkv0PfL-mv1Gm8_Nm-r522sucxCbJU2RUJ1YhShljDDrSiMBCESrotCaZ1kTChQRPFEs9SkRiRYa0shywoq2QI9nnKHh3868CGvS6-hqlQDbedzghnOUiIoHlByQrVrvXdg86Mra-X6AcpHkflZZD6KzEeRw83DOb4rajDTxb-5AdicgIMPagcToNzgqYIpUsg8HcsUPRF6r9yAsT-4MoxJ</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Derosa, Giuseppe</creator><creator>Tinelli, Carmine</creator><creator>D’Angelo, Angela</creator><creator>Ferrara, Gianluca</creator><creator>Bonaventura, Aldo</creator><creator>Bianchi, Lucio</creator><creator>Romano, Davide</creator><creator>Fogari, Elena</creator><creator>Maffioli, Pamela</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction</title><author>Derosa, Giuseppe ; Tinelli, Carmine ; D’Angelo, Angela ; Ferrara, Gianluca ; Bonaventura, Aldo ; Bianchi, Lucio ; Romano, Davide ; Fogari, Elena ; Maffioli, Pamela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-facdb62c6da12f13d4f5bd9e5564cbbacc6835aea1a46c37d7d560ccf2e88b293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Anxiety - complications</topic><topic>Anxiety - diagnosis</topic><topic>Anxiety - epidemiology</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>Clinical Trials as Topic</topic><topic>Depression - complications</topic><topic>Depression - diagnosis</topic><topic>Depression - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetic Angiopathies - blood</topic><topic>Diabetic Angiopathies - metabolism</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - blood</topic><topic>Erectile Dysfunction - complications</topic><topic>Erectile Dysfunction - metabolism</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hyperinsulinemia</topic><topic>International Index of Erectile Function (IIEF)</topic><topic>Male</topic><topic>Metabolome - physiology</topic><topic>Middle Aged</topic><topic>Self-Assessment</topic><topic>Surveys and Questionnaires</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Derosa, Giuseppe</creatorcontrib><creatorcontrib>Tinelli, Carmine</creatorcontrib><creatorcontrib>D’Angelo, Angela</creatorcontrib><creatorcontrib>Ferrara, Gianluca</creatorcontrib><creatorcontrib>Bonaventura, Aldo</creatorcontrib><creatorcontrib>Bianchi, Lucio</creatorcontrib><creatorcontrib>Romano, Davide</creatorcontrib><creatorcontrib>Fogari, Elena</creatorcontrib><creatorcontrib>Maffioli, Pamela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Derosa, Giuseppe</au><au>Tinelli, Carmine</au><au>D’Angelo, Angela</au><au>Ferrara, Gianluca</au><au>Bonaventura, Aldo</au><au>Bianchi, Lucio</au><au>Romano, Davide</au><au>Fogari, Elena</au><au>Maffioli, Pamela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2012</date><risdate>2012</risdate><volume>59</volume><issue>7</issue><spage>611</spage><epage>619</epage><pages>611-619</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>The aim of this study was to evaluate the glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction (ED). We evaluated 88 type 2 diabetic males, aged 62.78±9.26 years. We administered patients the IIEF (International Index of Erectile Function) questionnaire to assess erectile function, organ function, sexual desire, and satisfaction level during and after the sexual intercourse and the SAS (self-rating anxiety scale) and SDS (self-rating depression scale) questionnaires to evaluate anxiety and depression. We evaluated: BMI, abdominal circumference, glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA index, lipid profile, testosterone, free testosterone, dihydrotestosterone, and sex hormone binding globulin (SHBG). The IIEF questionnaire showed that in the examined sample there were 50 patients (56.8%) affected by ED, and 38 patients (43.2%) without ED. Comparing the two groups, 57.9% of patients without ED, and 70.0% of patients with ED were smokers, and the difference between the two groups was significant (p<0.05). Furthermore, 23.7% of patients without ED, and 38.0% of patients with ED had a history of chronic ischemic heart disease (p<0.05 between the two groups). Patients with ED were older, and, surprisingly, had lower levels of HbA1c. Furthermore, patients with ED had higher levels of FPI, and lower levels of testosterone and dihydrotestosterone. The prevalence of ED in Italian type 2 diabetic males with mean age of 62 years is about 56% and it is linked to higher levels of FPI, but lower levels of HbA1c, free testosterone and dihydrotestosterone.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>22572549</pmid><doi>10.1507/endocrj.EJ12-0117</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anxiety - complications Anxiety - diagnosis Anxiety - epidemiology Blood Glucose - metabolism Case-Control Studies Clinical Trials as Topic Depression - complications Depression - diagnosis Depression - epidemiology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetic Angiopathies - blood Diabetic Angiopathies - metabolism Erectile dysfunction Erectile Dysfunction - blood Erectile Dysfunction - complications Erectile Dysfunction - metabolism Glycated Hemoglobin A - analysis Glycated Hemoglobin A - metabolism Humans Hyperinsulinemia International Index of Erectile Function (IIEF) Male Metabolome - physiology Middle Aged Self-Assessment Surveys and Questionnaires Testosterone Testosterone - blood Type 2 diabetes mellitus |
| title | Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction |
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