Biological effects of conjugated linoleic acids supplementation
Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA...
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| Veröffentlicht in: | Polish journal of veterinary sciences 2012-01, Vol.15 (2), p.403-408 |
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| container_title | Polish journal of veterinary sciences |
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| creator | Oleszczuk, J. Oleszczuk, L. Siwicki, A. Skopińska-Różewska, E. |
| description | Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature. |
| doi_str_mv | 10.2478/v10181-012-0063-x |
| format | Article |
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The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature.</description><identifier>ISSN: 1505-1773</identifier><identifier>EISSN: 2300-2557</identifier><identifier>DOI: 10.2478/v10181-012-0063-x</identifier><identifier>PMID: 22844724</identifier><language>eng</language><publisher>Germany: Versita</publisher><subject>Animals ; Conjugated linoleic acids ; Dietary Supplements ; Humans ; immune response ; Insulin Resistance ; Linoleic Acids, Conjugated - pharmacology ; Neoplasms - prevention & control ; obesity ; Obesity - prevention & control ; tumors</subject><ispartof>Polish journal of veterinary sciences, 2012-01, Vol.15 (2), p.403-408</ispartof><rights>Copyright Polish Academy of Sciences, Committee of Veterinary Sciences 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-4ea68b4ff1e090688b326da0b642ef710b8e3b154cb9b6011aec7a147ccb599b3</citedby><cites>FETCH-LOGICAL-c466t-4ea68b4ff1e090688b326da0b642ef710b8e3b154cb9b6011aec7a147ccb599b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22844724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oleszczuk, J.</creatorcontrib><creatorcontrib>Oleszczuk, L.</creatorcontrib><creatorcontrib>Siwicki, A.</creatorcontrib><creatorcontrib>Skopińska-Różewska, E.</creatorcontrib><title>Biological effects of conjugated linoleic acids supplementation</title><title>Polish journal of veterinary sciences</title><addtitle>Pol J Vet Sci</addtitle><description>Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. 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The purpose of this review was to sum up the results available in the literature.</description><subject>Animals</subject><subject>Conjugated linoleic acids</subject><subject>Dietary Supplements</subject><subject>Humans</subject><subject>immune response</subject><subject>Insulin Resistance</subject><subject>Linoleic Acids, Conjugated - pharmacology</subject><subject>Neoplasms - prevention & control</subject><subject>obesity</subject><subject>Obesity - prevention & control</subject><subject>tumors</subject><issn>1505-1773</issn><issn>2300-2557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtu1DAUQC0EokPhA9igSGzYGHz9TFYVrSigtuJV1pbt3Iw8ZOIhTmD693WVtqqQWNmLc4-vDyEvgb3l0tTv_gCDGigDThnTgu4fkRUXjFGulHlMVqCYomCMOCDPct4UphG1fkoOOK-lNFyuyNFxTH1ax-D6CrsOw5Sr1FUhDZt57SZsqz4OqccYKhdim6s873Y9bnGY3BTT8Jw86Vyf8cXteUh-nn64PPlEz798_Hzy_pwGqfVEJTpde9l1gKxhuq694Lp1zGvJsTPAfI3Cg5LBN14zAIfBOJAmBK-axotD8mbx7sb0e8Y82W3MAfveDZjmbIEJVn4LDRT09T_oJs3jULYrFDdK1g03hYKFCmPKecTO7sa4deNVgexNXbvUtaWuvalr92Xm1a159lts7yfuchbgaAH-un7CscX1OF-Vy8MN_iMHxSUTxUAXQ8wT7u9fcOMvq40wyn67lPbH2cXpMXz9bi_ENaVamEE</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Oleszczuk, J.</creator><creator>Oleszczuk, L.</creator><creator>Siwicki, A.</creator><creator>Skopińska-Różewska, E.</creator><general>Versita</general><general>Polish Academy of Sciences, Committee of Veterinary Sciences</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Biological effects of conjugated linoleic acids supplementation</title><author>Oleszczuk, J. ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Conjugated linoleic acids Dietary Supplements Humans immune response Insulin Resistance Linoleic Acids, Conjugated - pharmacology Neoplasms - prevention & control obesity Obesity - prevention & control tumors |
| title | Biological effects of conjugated linoleic acids supplementation |
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