Developmental and Epigenetic Anomalies in Cloned Cattle

Many of the developmental anomalies observed in cloned animals are related to foetal and placental overgrowth, a phenomenon known as the ‘large offspring syndrome’ (LOS) in ruminants. It has been hypothesized that the epigenetic control of imprinted genes, that is, genes that are expressed in a pare...

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Veröffentlicht in:	Reproduction in domestic animals 2012-08, Vol.47 (s4), p.107-114
Hauptverfasser:	Smith, LC, Suzuki, J Jr, Goff, AK, Filion, F, Therrien, J, Murphy, BD, Kohan‐Ghadr, HR, Lefebvre, R, Brisville, AC, Buczinski, S, Fecteau, G, Perecin, F, Meirelles, FV
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles Animal reproduction Animals assisted reproductive technologies Breeding of animals Cattle Cattle - abnormalities Cattle - genetics cell nucleus Cloning Cloning, Organism - adverse effects Cloning, Organism - veterinary Developmental biology DNA early development Epigenesis, Genetic - genetics Epigenetics Female Gene Expression Regulation, Developmental - physiology hybrids in vitro culture methylation morbidity mortality Pregnancy progeny single nucleotide polymorphism somatic cells zebu
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