The CREB-Smad6-Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone

Fibrous dysplasia (FD) is characterized by the replacement of normal bone with abnormal fibro‐osseous tissue. This disorder is due to activating missense mutations in the GNAS gene and resultant over‐production of cAMP. However, the signalling pathways that contribute to FD pathogenesis remain unkno...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pathology 2012-09, Vol.228 (1), p.45-55
Hauptverfasser:	Fan, Qi-Ming, Yue, Bing, Bian, Zhen-Yu, Xu, Wen-Ting, Tu, Bing, Dai, Ke-Rong, Li, Gang, Tang, Ting-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Bone Morphogenetic Protein 2 - pharmacology Calcium - metabolism cAMP Cell Survival - drug effects Cells, Cultured Chromogranins Core Binding Factor Alpha 1 Subunit - metabolism CREB CREB-Binding Protein - metabolism Cyclic AMP - pharmacology Diseases of the osteoarticular system Female fibrous dysplasia Fibrous Dysplasia of Bone - genetics Fibrous Dysplasia of Bone - metabolism Fibrous Dysplasia of Bone - pathology Genetic Vectors GNAS GTP-Binding Protein alpha Subunits, Gs - genetics Humans Investigative techniques, diagnostic techniques (general aspects) Lentivirus Male Medical sciences Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mutation, Missense Osteogenesis - drug effects Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Recombinant Proteins Runx2 Signal Transduction Smad6 Smad6 Protein - metabolism Transduction, Genetic Tumors of striated muscle and skeleton Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!