Effects of progesterone on the content of CCR5 and CXCR4 coreceptors in PBMCs of seropositive and exposed but uninfected Mexican women to HIV-1

► P regulates HIV coreceptors in PBMCs from HIV seronegative and seropositive women. ► CCR5 expression is down-regulated while that of CXCR4 is up-regulated by P. ► In exposed but uninfected women to HIV, CCR5 and CXCR4 are down-regulated by P. ► P receptor isoforms (PR-A and PR-B) are expressed in...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2012-10, Vol.132 (1-2), p.66-72
Hauptverfasser:	Cabrera-Muñoz, Edith, Fuentes-Romero, Luis L., Zamora-Chávez, Jorge, Camacho-Arroyo, Ignacio, Soto-Ramírez, Luis E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult CCR5 Cells, Cultured CXCR4 Estradiol - blood Ethnic Groups Exposed uninfected Female HIV HIV Infections - metabolism HIV Seropositivity - metabolism HIV-1 Hormone Antagonists - pharmacology Humans Leukocytes, Mononuclear Middle Aged Mifepristone - pharmacology PBMC Progesterone Progesterone - blood Progesterone - pharmacology Progesterone receptor Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism Receptors, Progesterone - antagonists & inhibitors
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