Changing Face of Heart Failure Surgery
Abstract Background Heart failure is a serious disease ending with death if untreated. Although heart transplantation is the best therapy for end-stage heart failure, most candidates die in the waiting period due to the lack of donor organs. This condition represent a new era of heart failure surger...
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| Veröffentlicht in: | Transplantation proceedings 2012-07, Vol.44 (6), p.1729-1731 |
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| creator | Yagdi, T Oguz, E Engin, C Engin, Y Nalbantgil, S Zoghi, M Ozbaran, M |
| description | Abstract Background Heart failure is a serious disease ending with death if untreated. Although heart transplantation is the best therapy for end-stage heart failure, most candidates die in the waiting period due to the lack of donor organs. This condition represent a new era of heart failure surgery. Methods We retrospectively investigated 159 patients from 1998 to 2011 with a mean age of 40.0 years (range = 5–65), who were mostly diagnosed as dilated cardiomyopathy ( n = 113). After April 2007, 67 patients underwent vascular assist device (VAD) implantation surgery for acute or chronic end-stage heart failure. We performed 69 heart transplantation with 27 on VAD systems before transplantation. Results Early mortality was 13.3% with 21 patients after the heart transplantation. The 67 patients supported with VAD did not experience an intraoperative death. The mean support time was 214 days (range = 3–1035). Twenty-four patients (35.8%) are still on pump support. The overall survival until transplantation or weaning was 77.6% at mean of 250.7 days survival reached 90% with Heartware (Hartware Inc, Miramar, Fla, USA) continuous flow pumps. Conclusion After the introduction of VAD in 2007, the overall picture has been restructured radically for heart failure surgery, reducing patient loss on the waiting list. Especially, since 2009 nearly 80% of donor hearts were used for patients on mechanical circulatory support. |
| doi_str_mv | 10.1016/j.transproceed.2012.05.049 |
| format | Article |
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Although heart transplantation is the best therapy for end-stage heart failure, most candidates die in the waiting period due to the lack of donor organs. This condition represent a new era of heart failure surgery. Methods We retrospectively investigated 159 patients from 1998 to 2011 with a mean age of 40.0 years (range = 5–65), who were mostly diagnosed as dilated cardiomyopathy ( n = 113). After April 2007, 67 patients underwent vascular assist device (VAD) implantation surgery for acute or chronic end-stage heart failure. We performed 69 heart transplantation with 27 on VAD systems before transplantation. Results Early mortality was 13.3% with 21 patients after the heart transplantation. The 67 patients supported with VAD did not experience an intraoperative death. The mean support time was 214 days (range = 3–1035). Twenty-four patients (35.8%) are still on pump support. The overall survival until transplantation or weaning was 77.6% at mean of 250.7 days survival reached 90% with Heartware (Hartware Inc, Miramar, Fla, USA) continuous flow pumps. Conclusion After the introduction of VAD in 2007, the overall picture has been restructured radically for heart failure surgery, reducing patient loss on the waiting list. Especially, since 2009 nearly 80% of donor hearts were used for patients on mechanical circulatory support.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2012.05.049</identifier><identifier>PMID: 22841256</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - instrumentation ; Cardiac Surgical Procedures - mortality ; Cardiac Surgical Procedures - trends ; Cardiology. Vascular system ; Child ; Child, Preschool ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Heart ; Heart Failure - diagnosis ; Heart Failure - mortality ; Heart Failure - physiopathology ; Heart Failure - surgery ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart Transplantation - adverse effects ; Heart Transplantation - mortality ; Heart Transplantation - trends ; Heart-Assist Devices - adverse effects ; Heart-Assist Devices - trends ; Hospital Mortality ; Humans ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Retrospective Studies ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Time Factors ; Tissue, organ and graft immunology ; Treatment Outcome ; Turkey ; Waiting Lists ; Young Adult</subject><ispartof>Transplantation proceedings, 2012-07, Vol.44 (6), p.1729-1731</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-45195a1c2ae58956f1b6a3992e4faf6c7ed1f3913355251a018d0eee67f4e71d3</citedby><cites>FETCH-LOGICAL-c465t-45195a1c2ae58956f1b6a3992e4faf6c7ed1f3913355251a018d0eee67f4e71d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2012.05.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,781,785,790,791,3551,23935,23936,25145,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26450600$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22841256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yagdi, T</creatorcontrib><creatorcontrib>Oguz, E</creatorcontrib><creatorcontrib>Engin, C</creatorcontrib><creatorcontrib>Engin, Y</creatorcontrib><creatorcontrib>Nalbantgil, S</creatorcontrib><creatorcontrib>Zoghi, M</creatorcontrib><creatorcontrib>Ozbaran, M</creatorcontrib><title>Changing Face of Heart Failure Surgery</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background Heart failure is a serious disease ending with death if untreated. Although heart transplantation is the best therapy for end-stage heart failure, most candidates die in the waiting period due to the lack of donor organs. This condition represent a new era of heart failure surgery. Methods We retrospectively investigated 159 patients from 1998 to 2011 with a mean age of 40.0 years (range = 5–65), who were mostly diagnosed as dilated cardiomyopathy ( n = 113). After April 2007, 67 patients underwent vascular assist device (VAD) implantation surgery for acute or chronic end-stage heart failure. We performed 69 heart transplantation with 27 on VAD systems before transplantation. Results Early mortality was 13.3% with 21 patients after the heart transplantation. The 67 patients supported with VAD did not experience an intraoperative death. The mean support time was 214 days (range = 3–1035). Twenty-four patients (35.8%) are still on pump support. The overall survival until transplantation or weaning was 77.6% at mean of 250.7 days survival reached 90% with Heartware (Hartware Inc, Miramar, Fla, USA) continuous flow pumps. Conclusion After the introduction of VAD in 2007, the overall picture has been restructured radically for heart failure surgery, reducing patient loss on the waiting list. Especially, since 2009 nearly 80% of donor hearts were used for patients on mechanical circulatory support.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiac Surgical Procedures - instrumentation</subject><subject>Cardiac Surgical Procedures - mortality</subject><subject>Cardiac Surgical Procedures - trends</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Heart</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - surgery</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Heart Transplantation - adverse effects</subject><subject>Heart Transplantation - mortality</subject><subject>Heart Transplantation - trends</subject><subject>Heart-Assist Devices - adverse effects</subject><subject>Heart-Assist Devices - trends</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><subject>Turkey</subject><subject>Waiting Lists</subject><subject>Young Adult</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1PGzEQhq0KVALtX6iiSqBedpnx12Y5IKGUFCQkDrRny3jHqdPNLti7SPn3OEpQq544WSM_8479DGNfEUoE1Oercoi2S0-xd0RNyQF5CaoEWX9gE5xVouCaiwM2AZBYoJDqiB2ntIJccyk-siPOZxK50hN2Nv9tu2XoltOFdTTt_fSGbBxyFdox0vRhjEuKm0_s0Ns20ef9ecJ-La5_zm-Ku_sft_Oru8JJrYZCKqyVRcctqVmttMdHbUVdc5Leeu0qatCLGoVQiiu0gLMGiEhXXlKFjThh33a5-XPPI6XBrENy1La2o35MBkGAUFxWdUYvdqiLfUqRvHmKYW3jJkNm68mszL-ezNaTAWWyp9z8ZT9nfFznu7fWNzEZON0DNjnb-hzkQvrLaalAA2Tu-46jbOUlUDTJBeocNSGSG0zTh_e95_K_GNeGLuTJf2hDadWPscveDZqUe8zDdrPbxSIHUCiFeAVas593</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Yagdi, T</creator><creator>Oguz, E</creator><creator>Engin, C</creator><creator>Engin, Y</creator><creator>Nalbantgil, S</creator><creator>Zoghi, M</creator><creator>Ozbaran, M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Changing Face of Heart Failure Surgery</title><author>Yagdi, T ; Oguz, E ; Engin, C ; Engin, Y ; Nalbantgil, S ; Zoghi, M ; Ozbaran, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-45195a1c2ae58956f1b6a3992e4faf6c7ed1f3913355251a018d0eee67f4e71d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiac Surgical Procedures - instrumentation</topic><topic>Cardiac Surgical Procedures - mortality</topic><topic>Cardiac Surgical Procedures - trends</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Heart</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - surgery</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Heart Transplantation - adverse effects</topic><topic>Heart Transplantation - mortality</topic><topic>Heart Transplantation - trends</topic><topic>Heart-Assist Devices - adverse effects</topic><topic>Heart-Assist Devices - trends</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><topic>Turkey</topic><topic>Waiting Lists</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yagdi, T</creatorcontrib><creatorcontrib>Oguz, E</creatorcontrib><creatorcontrib>Engin, C</creatorcontrib><creatorcontrib>Engin, Y</creatorcontrib><creatorcontrib>Nalbantgil, S</creatorcontrib><creatorcontrib>Zoghi, M</creatorcontrib><creatorcontrib>Ozbaran, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yagdi, T</au><au>Oguz, E</au><au>Engin, C</au><au>Engin, Y</au><au>Nalbantgil, S</au><au>Zoghi, M</au><au>Ozbaran, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Face of Heart Failure Surgery</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>44</volume><issue>6</issue><spage>1729</spage><epage>1731</epage><pages>1729-1731</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Background Heart failure is a serious disease ending with death if untreated. Although heart transplantation is the best therapy for end-stage heart failure, most candidates die in the waiting period due to the lack of donor organs. This condition represent a new era of heart failure surgery. Methods We retrospectively investigated 159 patients from 1998 to 2011 with a mean age of 40.0 years (range = 5–65), who were mostly diagnosed as dilated cardiomyopathy ( n = 113). After April 2007, 67 patients underwent vascular assist device (VAD) implantation surgery for acute or chronic end-stage heart failure. We performed 69 heart transplantation with 27 on VAD systems before transplantation. Results Early mortality was 13.3% with 21 patients after the heart transplantation. The 67 patients supported with VAD did not experience an intraoperative death. The mean support time was 214 days (range = 3–1035). Twenty-four patients (35.8%) are still on pump support. The overall survival until transplantation or weaning was 77.6% at mean of 250.7 days survival reached 90% with Heartware (Hartware Inc, Miramar, Fla, USA) continuous flow pumps. Conclusion After the introduction of VAD in 2007, the overall picture has been restructured radically for heart failure surgery, reducing patient loss on the waiting list. Especially, since 2009 nearly 80% of donor hearts were used for patients on mechanical circulatory support.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22841256</pmid><doi>10.1016/j.transproceed.2012.05.049</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - instrumentation Cardiac Surgical Procedures - mortality Cardiac Surgical Procedures - trends Cardiology. Vascular system Child Child, Preschool Female Fundamental and applied biological sciences. Psychology Fundamental immunology Heart Heart Failure - diagnosis Heart Failure - mortality Heart Failure - physiopathology Heart Failure - surgery Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Transplantation - adverse effects Heart Transplantation - mortality Heart Transplantation - trends Heart-Assist Devices - adverse effects Heart-Assist Devices - trends Hospital Mortality Humans Male Medical sciences Middle Aged Postoperative Complications - etiology Postoperative Complications - mortality Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors Tissue, organ and graft immunology Treatment Outcome Turkey Waiting Lists Young Adult |
| title | Changing Face of Heart Failure Surgery |
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