Synthesis and biological activity of novel mycophenolic acid conjugates containing nitro-acridine/acridone derivatives

Hybrid pharmacophore anti-proliferative compounds, comprised of mycophenolic acid (MPA) and 1-nitroacridine/4-nitroacridone derivative have been synthesized and evaluated as inhibitors of five different leukemia cell lines (Jurkat, Molt-4, HL-60, CCRF-CEM, L1210) and human peripheral blood mononucle...

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Veröffentlicht in:	European journal of medicinal chemistry 2012-08, Vol.54, p.197-201
Hauptverfasser:	Malachowska-Ugarte, Magdalena, Cholewinski, Grzegorz, Dzierzbicka, Krystyna, Trzonkowski, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridine/acridone derivatives Acridines - chemistry Acridones - chemistry Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Chemistry Techniques, Synthetic Humans Immunosuppressive Agents - chemical synthesis Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology IMP Dehydrogenase - antagonists & inhibitors Inhibitory Concentration 50 Medical sciences Miscellaneous MPA Mycophenolic acid Mycophenolic Acid - chemical synthesis Mycophenolic Acid - chemistry Mycophenolic Acid - pharmacology Mycophenolic acid derivatives Pharmacology. Drug treatments
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