Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways

Introduction We have previously demonstrated that transforming growth factor-β (TGF-β) in the presence of elevated levels of Smad3, its primary signaling protein, stimulates rat vascular smooth muscle cell (VSMC) proliferation and intimal hyperplasia. The mechanism is partly through the nuclear expo...

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Veröffentlicht in:	Journal of vascular surgery 2012-08, Vol.56 (2), p.446-454.e1
Hauptverfasser:	Suwanabol, Pasithorn A., MD, Seedial, Stephen M., BS, Shi, Xudong, MD, PhD, Zhang, Fan, MD, PhD, Yamanouchi, Dai, MD, PhD, Roenneburg, Drew, MS, Liu, Bo, PhD, Kent, K. Craig, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Aorta - cytology Biological and medical sciences Cell Proliferation Cell Survival Emergency and intensive care: renal failure. Dialysis management Extracellular Signal-Regulated MAP Kinases - physiology Immunohistochemistry Intensive care medicine Male Medical sciences Muscle, Smooth, Vascular - cytology Phosphorylation Rats Rats, Sprague-Dawley Smad3 Protein - metabolism Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transforming Growth Factor beta - physiology Up-Regulation - physiology Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
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