SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors

Herein we describe the SAR of a novel series of 6-aryl-2-amino-triazolopyridines as potent and selective PI3Kγ inhibitors. The 6-aryl-triazolopyridine core was identified by chemoproteomic screening of a kinase focused library. Rapid chemical expansion around a bi-functional core identified the key...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2012-08, Vol.22 (16), p.5257-5263
Hauptverfasser: Bell, Kathryn, Sunose, Mihiro, Ellard, Katie, Cansfield, Andrew, Taylor, Jess, Miller, Warren, Ramsden, Nigel, Bergamini, Giovanna, Neubauer, Gitte
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Sprache:eng
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