A novel delivery system of doxorubicin with high load and pH-responsive release from the nanoparticles of poly (α,β-aspartic acid) derivative

A poly (amino acid)-based amphiphilic copolymer was utilized to fabricate a better micellar drug delivery system (DDS) with improved compatibility and sustained release of doxorubicin (DOX). First, poly (ethylene glycol) monomethyl ether (mPEG) and DOX were conjugated onto polyasparihyazide (PAHy),...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2012-08, Vol.47 (1), p.256-264
Hauptverfasser:	Wang, Xiaojuan, Wu, Guolin, Lu, Caicai, Zhao, Weipeng, Wang, Yinong, Fan, Yunge, Gao, Hui, Ma, Jianbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid - administration & dosage Aspartic Acid - chemistry Biological and medical sciences Cells, Cultured DOX Doxorubicin - administration & dosage Doxorubicin - chemistry Drug delivery system Drug Delivery Systems - methods General pharmacology Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Loading capacity Medical sciences Micelles Nanoparticles - administration & dosage Nanoparticles - chemistry pH-responsiveness Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyasparihyazide Polyethylene Glycols - chemistry Polymers - administration & dosage Polymers - chemical synthesis Polymers - chemistry
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