To differentiate or not — routes towards metastasis

Why are many metastases differentiated? This Opinion article proposes that this is due to phenotypic plasticity involving transient epithelial–mesenchymal transition (EMT). In undifferentiated metastasis, it might be that cells are genetically locked into an undifferentiated state. The therapeutic c...

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Veröffentlicht in:	Nature reviews. Cancer 2012-06, Vol.12 (6), p.425-436
1. Verfasser:	Brabletz, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/84/2176 71 Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma Cell Differentiation Colorectal cancer Development and progression Dormancy Epithelial-Mesenchymal Transition Gene expression Genetic aspects Humans Metastases Metastasis Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology opinion-2 phenotypic plasticity Stem cells Stem Cells - pathology Tropism
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