A Multicenter, Double-blind Study to Evaluate the Efficacy and Safety of 2 Treatments in Participants With Mild to Moderate Acne Vulgaris
Acne treatment regimens have changed due to the recent over-the-counter (OTC) switch of all prescription benzoyl peroxide (BPO) topical preparations. The elimination of prescription single-agent BPO products means that dermatologists must select from a variety of OTC formulations to utilize the time...
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| Veröffentlicht in: | Cutis (New York, N.Y.) N.Y.), 2012-06, Vol.89 (6), p.287-293 |
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| container_title | Cutis (New York, N.Y.) |
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| creator | DIANA DRAELOS, Zoe SHALITA, Alan R THIBOUTOT, Diane ORESAJO, Christian YATSKAYER, Margarita RAAB, Susanna |
| description | Acne treatment regimens have changed due to the recent over-the-counter (OTC) switch of all prescription benzoyl peroxide (BPO) topical preparations. The elimination of prescription single-agent BPO products means that dermatologists must select from a variety of OTC formulations to utilize the time-tested efficacy of BPO in the treatment of mild to moderate acne. Our research compared the efficacy and safety of an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% with prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025%. Parity was demonstrated between the 2 treatment regimens at 12 weeks. |
| format | Article |
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The elimination of prescription single-agent BPO products means that dermatologists must select from a variety of OTC formulations to utilize the time-tested efficacy of BPO in the treatment of mild to moderate acne. Our research compared the efficacy and safety of an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% with prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025%. Parity was demonstrated between the 2 treatment regimens at 12 weeks.</description><identifier>ISSN: 0011-4162</identifier><identifier>EISSN: 2326-6929</identifier><identifier>PMID: 22838094</identifier><identifier>CODEN: CUTIBC</identifier><language>eng</language><publisher>Plainview, NY: Quadrant HealthCom</publisher><subject><![CDATA[Acne Vulgaris - drug therapy ; Acne Vulgaris - pathology ; Adolescent ; Adult ; Benzoyl Peroxide - administration & dosage ; Benzoyl Peroxide - adverse effects ; Benzoyl Peroxide - therapeutic use ; Biological and medical sciences ; Clindamycin - administration & dosage ; Clindamycin - adverse effects ; Clindamycin - therapeutic use ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - adverse effects ; Dermatologic Agents - therapeutic use ; Dermatology ; Double-Blind Method ; Drug Combinations ; Drug Therapy, Combination ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nonprescription Drugs - administration & dosage ; Nonprescription Drugs - adverse effects ; Nonprescription Drugs - therapeutic use ; Salicylates - administration & dosage ; Salicylates - adverse effects ; Salicylates - therapeutic use ; Skin involvement in other diseases. 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General aspects ; Treatment Outcome ; Tretinoin - administration & dosage ; Tretinoin - adverse effects ; Tretinoin - therapeutic use ; Young Adult]]></subject><ispartof>Cutis (New York, N.Y.), 2012-06, Vol.89 (6), p.287-293</ispartof><rights>2015 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26029282$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22838094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DIANA DRAELOS, Zoe</creatorcontrib><creatorcontrib>SHALITA, Alan R</creatorcontrib><creatorcontrib>THIBOUTOT, Diane</creatorcontrib><creatorcontrib>ORESAJO, Christian</creatorcontrib><creatorcontrib>YATSKAYER, Margarita</creatorcontrib><creatorcontrib>RAAB, Susanna</creatorcontrib><title>A Multicenter, Double-blind Study to Evaluate the Efficacy and Safety of 2 Treatments in Participants With Mild to Moderate Acne Vulgaris</title><title>Cutis (New York, N.Y.)</title><addtitle>Cutis</addtitle><description>Acne treatment regimens have changed due to the recent over-the-counter (OTC) switch of all prescription benzoyl peroxide (BPO) topical preparations. The elimination of prescription single-agent BPO products means that dermatologists must select from a variety of OTC formulations to utilize the time-tested efficacy of BPO in the treatment of mild to moderate acne. Our research compared the efficacy and safety of an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% with prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025%. Parity was demonstrated between the 2 treatment regimens at 12 weeks.</description><subject>Acne Vulgaris - drug therapy</subject><subject>Acne Vulgaris - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Benzoyl Peroxide - administration & dosage</subject><subject>Benzoyl Peroxide - adverse effects</subject><subject>Benzoyl Peroxide - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clindamycin - administration & dosage</subject><subject>Clindamycin - adverse effects</subject><subject>Clindamycin - therapeutic use</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - adverse effects</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dermatology</subject><subject>Double-Blind Method</subject><subject>Drug Combinations</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nonprescription Drugs - administration & dosage</subject><subject>Nonprescription Drugs - adverse effects</subject><subject>Nonprescription Drugs - therapeutic use</subject><subject>Salicylates - administration & dosage</subject><subject>Salicylates - adverse effects</subject><subject>Salicylates - therapeutic use</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Treatment Outcome</subject><subject>Tretinoin - administration & dosage</subject><subject>Tretinoin - adverse effects</subject><subject>Tretinoin - therapeutic use</subject><subject>Young Adult</subject><issn>0011-4162</issn><issn>2326-6929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAUhosobk7_guRG8MJCPro2uRxzfsCGgkMvy0mauEjaziQV-hP817Y48erwvjw88J6jZEoZzdNcUHGcTDEmJM1ITifJWQgfQxS0KE6TCaWccSyyafK9QJvORat0E7W_QbdtJ51OpbNNhV5iV_Uotmj1Ba6DqFHcabQyxipQPYIRAaNjj1qDKNp6DbEeRAHZBj2DH7R2D2N-s3GHNtZVo23TVtqPtoVqNHrt3Dt4G86TEwMu6IvDnSXbu9V2-ZCun-4fl4t1uqcZiangXIEwhajmGDJisJRFbgQjopIi55jPyVAyJYkmEjCXjJlsXkgsWD7OniXXv9q9bz87HWJZ26C0c9DotgslwQyzjHNKB_TygHay1lW597YG35d_3xuAqwMAQYEzHhplwz-XYyoop-wHE_x46A</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>DIANA DRAELOS, Zoe</creator><creator>SHALITA, Alan R</creator><creator>THIBOUTOT, Diane</creator><creator>ORESAJO, Christian</creator><creator>YATSKAYER, Margarita</creator><creator>RAAB, Susanna</creator><general>Quadrant HealthCom</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>A Multicenter, Double-blind Study to Evaluate the Efficacy and Safety of 2 Treatments in Participants With Mild to Moderate Acne Vulgaris</title><author>DIANA DRAELOS, Zoe ; SHALITA, Alan R ; THIBOUTOT, Diane ; ORESAJO, Christian ; YATSKAYER, Margarita ; RAAB, Susanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-988ca9f79d50a41f0bb76f9319db96808511f03cb1e1ba08b33f457b09362283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acne Vulgaris - drug therapy</topic><topic>Acne Vulgaris - pathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Benzoyl Peroxide - administration & dosage</topic><topic>Benzoyl Peroxide - adverse effects</topic><topic>Benzoyl Peroxide - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clindamycin - administration & dosage</topic><topic>Clindamycin - adverse effects</topic><topic>Clindamycin - therapeutic use</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - adverse effects</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dermatology</topic><topic>Double-Blind Method</topic><topic>Drug Combinations</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nonprescription Drugs - administration & dosage</topic><topic>Nonprescription Drugs - adverse effects</topic><topic>Nonprescription Drugs - therapeutic use</topic><topic>Salicylates - administration & dosage</topic><topic>Salicylates - adverse effects</topic><topic>Salicylates - therapeutic use</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Treatment Outcome</topic><topic>Tretinoin - administration & dosage</topic><topic>Tretinoin - adverse effects</topic><topic>Tretinoin - therapeutic use</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>DIANA DRAELOS, Zoe</creatorcontrib><creatorcontrib>SHALITA, Alan R</creatorcontrib><creatorcontrib>THIBOUTOT, Diane</creatorcontrib><creatorcontrib>ORESAJO, Christian</creatorcontrib><creatorcontrib>YATSKAYER, Margarita</creatorcontrib><creatorcontrib>RAAB, Susanna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cutis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DIANA DRAELOS, Zoe</au><au>SHALITA, Alan R</au><au>THIBOUTOT, Diane</au><au>ORESAJO, Christian</au><au>YATSKAYER, Margarita</au><au>RAAB, Susanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Multicenter, Double-blind Study to Evaluate the Efficacy and Safety of 2 Treatments in Participants With Mild to Moderate Acne Vulgaris</atitle><jtitle>Cutis (New York, N.Y.)</jtitle><addtitle>Cutis</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>89</volume><issue>6</issue><spage>287</spage><epage>293</epage><pages>287-293</pages><issn>0011-4162</issn><eissn>2326-6929</eissn><coden>CUTIBC</coden><abstract>Acne treatment regimens have changed due to the recent over-the-counter (OTC) switch of all prescription benzoyl peroxide (BPO) topical preparations. The elimination of prescription single-agent BPO products means that dermatologists must select from a variety of OTC formulations to utilize the time-tested efficacy of BPO in the treatment of mild to moderate acne. Our research compared the efficacy and safety of an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% with prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025%. Parity was demonstrated between the 2 treatment regimens at 12 weeks.</abstract><cop>Plainview, NY</cop><pub>Quadrant HealthCom</pub><pmid>22838094</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Cutis (New York, N.Y.), 2012-06, Vol.89 (6), p.287-293 |
| issn | 0011-4162 2326-6929 |
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| subjects | Acne Vulgaris - drug therapy Acne Vulgaris - pathology Adolescent Adult Benzoyl Peroxide - administration & dosage Benzoyl Peroxide - adverse effects Benzoyl Peroxide - therapeutic use Biological and medical sciences Clindamycin - administration & dosage Clindamycin - adverse effects Clindamycin - therapeutic use Dermatologic Agents - administration & dosage Dermatologic Agents - adverse effects Dermatologic Agents - therapeutic use Dermatology Double-Blind Method Drug Combinations Drug Therapy, Combination Female Humans Male Medical sciences Middle Aged Nonprescription Drugs - administration & dosage Nonprescription Drugs - adverse effects Nonprescription Drugs - therapeutic use Salicylates - administration & dosage Salicylates - adverse effects Salicylates - therapeutic use Skin involvement in other diseases. Miscellaneous. General aspects Treatment Outcome Tretinoin - administration & dosage Tretinoin - adverse effects Tretinoin - therapeutic use Young Adult |
| title | A Multicenter, Double-blind Study to Evaluate the Efficacy and Safety of 2 Treatments in Participants With Mild to Moderate Acne Vulgaris |
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