Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave
γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we u...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2012-07, Vol.37 (1), p.48-59 |
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| creator | Haas, Jan D. Ravens, Sarina Düber, Sandra Sandrock, Inga Oberdörfer, Linda Kashani, Elham Chennupati, Vijaykumar Föhse, Lisa Naumann, Ronald Weiss, Siegfried Krueger, Andreas Förster, Reinhold Prinz, Immo |
| description | γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.
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► Development of γδT17 cells is restricted to a “functional embryonic wave” ► IL-17 itself appears to be involved in the restricting mechanism ► γδT17 cells are long-lived, self-renewing, and radioresistant ► We identify a thymic population of innate IL-17-producing lymphocytes |
| doi_str_mv | 10.1016/j.immuni.2012.06.003 |
| format | Article |
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[Display omitted]
► Development of γδT17 cells is restricted to a “functional embryonic wave” ► IL-17 itself appears to be involved in the restricting mechanism ► γδT17 cells are long-lived, self-renewing, and radioresistant ► We identify a thymic population of innate IL-17-producing lymphocytes</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2012.06.003</identifier><identifier>PMID: 22770884</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Bone Marrow - metabolism ; Chimerism ; Homeostasis - immunology ; Immunity, Innate ; Interleukin-17 - biosynthesis ; Interleukin-17 - deficiency ; Interleukin-17 - genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Antigen, T-Cell, alpha-beta - immunology ; Receptors, Antigen, T-Cell, alpha-beta - metabolism ; Receptors, Antigen, T-Cell, gamma-delta - immunology ; Receptors, Antigen, T-Cell, gamma-delta - metabolism ; Receptors, CCR6 - metabolism ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; Thymocytes - cytology ; Thymocytes - immunology ; Thymocytes - metabolism ; Thymus Gland - embryology ; Thymus Gland - metabolism ; Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism</subject><ispartof>Immunity (Cambridge, Mass.), 2012-07, Vol.37 (1), p.48-59</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3233-dbf38200753186250e7466fdfd8d25577b6c0f7b9341da8a465a3e9ee002e7433</citedby><cites>FETCH-LOGICAL-c3233-dbf38200753186250e7466fdfd8d25577b6c0f7b9341da8a465a3e9ee002e7433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1074761312002403$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22770884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haas, Jan D.</creatorcontrib><creatorcontrib>Ravens, Sarina</creatorcontrib><creatorcontrib>Düber, Sandra</creatorcontrib><creatorcontrib>Sandrock, Inga</creatorcontrib><creatorcontrib>Oberdörfer, Linda</creatorcontrib><creatorcontrib>Kashani, Elham</creatorcontrib><creatorcontrib>Chennupati, Vijaykumar</creatorcontrib><creatorcontrib>Föhse, Lisa</creatorcontrib><creatorcontrib>Naumann, Ronald</creatorcontrib><creatorcontrib>Weiss, Siegfried</creatorcontrib><creatorcontrib>Krueger, Andreas</creatorcontrib><creatorcontrib>Förster, Reinhold</creatorcontrib><creatorcontrib>Prinz, Immo</creatorcontrib><title>Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.
[Display omitted]
► Development of γδT17 cells is restricted to a “functional embryonic wave” ► IL-17 itself appears to be involved in the restricting mechanism ► γδT17 cells are long-lived, self-renewing, and radioresistant ► We identify a thymic population of innate IL-17-producing lymphocytes</description><subject>Animals</subject><subject>Bone Marrow - metabolism</subject><subject>Chimerism</subject><subject>Homeostasis - immunology</subject><subject>Immunity, Innate</subject><subject>Interleukin-17 - biosynthesis</subject><subject>Interleukin-17 - deficiency</subject><subject>Interleukin-17 - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - metabolism</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - immunology</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - metabolism</subject><subject>Receptors, CCR6 - metabolism</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Thymocytes - cytology</subject><subject>Thymocytes - immunology</subject><subject>Thymocytes - metabolism</subject><subject>Thymus Gland - embryology</subject><subject>Thymus Gland - metabolism</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuO1DAQhiMEYh5wA4S8ZJNQjh3b2SChZoZpaSQQGsTScuwKcpPYjZ20NOeCc8yZcKsHlqyqFt9fj6-qXlFoKFDxdtf4eV6Db1qgbQOiAWBPqnMKvaw5VfD02EteS0HZWXWR8w6A8q6H59VZ20oJSvHzynzAA05xP2NYSBzJNiyYJlx_-FBTWX9O0a3Wh-_k4dfDb3JHNjhNmWwz-YJ5Sd4u6MgSiSHXa7CLj8FM5Goe0n0M3pJv5oAvqmejmTK-fKyX1dfrq7vNTX376eN28_62tqxlrHbDyFQLIDtGlWg7QMmFGN3olGu7TspBWBjl0DNOnVGGi84w7BEB2oIydlm9Oc3dp_hzLdfp2WdbzjUB45o1BQaMKwV9QfkJtSnmnHDU--Rnk-4LpI9y9U6f5OqjXA1CF7kl9vpxwzrM6P6F_toswLsTgOXPg8eks_UYLDqf0C7aRf__DX8AnA2NGg</recordid><startdate>20120727</startdate><enddate>20120727</enddate><creator>Haas, Jan D.</creator><creator>Ravens, Sarina</creator><creator>Düber, Sandra</creator><creator>Sandrock, Inga</creator><creator>Oberdörfer, Linda</creator><creator>Kashani, Elham</creator><creator>Chennupati, Vijaykumar</creator><creator>Föhse, Lisa</creator><creator>Naumann, Ronald</creator><creator>Weiss, Siegfried</creator><creator>Krueger, Andreas</creator><creator>Förster, Reinhold</creator><creator>Prinz, Immo</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120727</creationdate><title>Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave</title><author>Haas, Jan D. ; Ravens, Sarina ; Düber, Sandra ; Sandrock, Inga ; Oberdörfer, Linda ; Kashani, Elham ; Chennupati, Vijaykumar ; Föhse, Lisa ; Naumann, Ronald ; Weiss, Siegfried ; Krueger, Andreas ; Förster, Reinhold ; Prinz, Immo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3233-dbf38200753186250e7466fdfd8d25577b6c0f7b9341da8a465a3e9ee002e7433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bone Marrow - metabolism</topic><topic>Chimerism</topic><topic>Homeostasis - immunology</topic><topic>Immunity, Innate</topic><topic>Interleukin-17 - biosynthesis</topic><topic>Interleukin-17 - deficiency</topic><topic>Interleukin-17 - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - immunology</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - metabolism</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - immunology</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - metabolism</topic><topic>Receptors, CCR6 - metabolism</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Thymocytes - cytology</topic><topic>Thymocytes - immunology</topic><topic>Thymocytes - metabolism</topic><topic>Thymus Gland - embryology</topic><topic>Thymus Gland - metabolism</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haas, Jan D.</creatorcontrib><creatorcontrib>Ravens, Sarina</creatorcontrib><creatorcontrib>Düber, Sandra</creatorcontrib><creatorcontrib>Sandrock, Inga</creatorcontrib><creatorcontrib>Oberdörfer, Linda</creatorcontrib><creatorcontrib>Kashani, Elham</creatorcontrib><creatorcontrib>Chennupati, Vijaykumar</creatorcontrib><creatorcontrib>Föhse, Lisa</creatorcontrib><creatorcontrib>Naumann, Ronald</creatorcontrib><creatorcontrib>Weiss, Siegfried</creatorcontrib><creatorcontrib>Krueger, Andreas</creatorcontrib><creatorcontrib>Förster, Reinhold</creatorcontrib><creatorcontrib>Prinz, Immo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haas, Jan D.</au><au>Ravens, Sarina</au><au>Düber, Sandra</au><au>Sandrock, Inga</au><au>Oberdörfer, Linda</au><au>Kashani, Elham</au><au>Chennupati, Vijaykumar</au><au>Föhse, Lisa</au><au>Naumann, Ronald</au><au>Weiss, Siegfried</au><au>Krueger, Andreas</au><au>Förster, Reinhold</au><au>Prinz, Immo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2012-07-27</date><risdate>2012</risdate><volume>37</volume><issue>1</issue><spage>48</spage><epage>59</epage><pages>48-59</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.
[Display omitted]
► Development of γδT17 cells is restricted to a “functional embryonic wave” ► IL-17 itself appears to be involved in the restricting mechanism ► γδT17 cells are long-lived, self-renewing, and radioresistant ► We identify a thymic population of innate IL-17-producing lymphocytes</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22770884</pmid><doi>10.1016/j.immuni.2012.06.003</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bone Marrow - metabolism Chimerism Homeostasis - immunology Immunity, Innate Interleukin-17 - biosynthesis Interleukin-17 - deficiency Interleukin-17 - genetics Mice Mice, Inbred C57BL Mice, Knockout Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, alpha-beta - metabolism Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Antigen, T-Cell, gamma-delta - metabolism Receptors, CCR6 - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymocytes - cytology Thymocytes - immunology Thymocytes - metabolism Thymus Gland - embryology Thymus Gland - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism |
| title | Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave |
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