Characterization of internal structure, polymer erosion and drug release mechanisms of biodegradable poly(ester anhydride)s by X-ray microtomography

Surface-eroding biodegradable polymers can provide many advantages in drug delivery, such as controllable and zero-order drug release. Photocrosslinkable poly(ester anhydride)s are a recently developed family of surface-eroding polymers with readily modifiable oligomer chemistry allowing tailoring o...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2012-08, Vol.47 (1), p.170-178
Hauptverfasser:	Mönkäre, Juha, Pajander, Jari, Hakala, Risto A., Savolainen, Pekka, Järveläinen, Maija, Korhonen, Harri, Seppälä, Jukka V., Järvinen, Kristiina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anhydrides - chemistry Biological and medical sciences Buffers Bulk erosion Drug Delivery Systems - methods Drug release mechanism General pharmacology Hydrophobic and Hydrophilic Interactions Medical sciences Micro-CT Particle Size Peptides - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(ester anhydride)s Polyesters - chemistry Polymer erosion mechanism Polymers - chemistry Propranolol - chemistry Solutions - chemistry Surface erosion X-Ray Microtomography - methods
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