Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms

Ca(V)2.2 (N-type) calcium channels control the entry of calcium into neurons to regulate essential functions but most notably presynaptic transmitter release. Ca(V)2.2 channel expression levels are precisely controlled, but we know little of the cellular mechanisms involved. The ubiquitin proteasome...

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Veröffentlicht in:	The Journal of neuroscience 2012-07, Vol.32 (30), p.10365-10369
Hauptverfasser:	Marangoudakis, Spiro, Andrade, Arturo, Helton, Thomas D, Denome, Sylvia, Castiglioni, Andrew J, Lipscombe, Diane
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Calcium Channels, N-Type - genetics Calcium Channels, N-Type - metabolism Ganglia, Spinal - metabolism Mice Neurons - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Ubiquitination - physiology
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