miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma

► miR-376a was found frequently down-regulated in HCC cell lines and tissues. ► Over-expression of miR-376a in Huh7 cells inhibited proliferation and induced apoptosis. ► p85α (PIK3R1) was identified as a direct and functional target of miR-376a in Huh7 cells. ► Down-regulation of miR-376a may contr...

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Veröffentlicht in:	FEBS letters 2012-07, Vol.586 (16), p.2396-2403
Hauptverfasser:	Zheng, Yongxia, Yin, Lei, Chen, Huan, Yang, Shengsheng, Pan, Chuanyong, Lu, Shan, Miao, Mingyong, Jiao, Binghua
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - biosynthesis Animals Apoptosis Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cell Proliferation Down-Regulation Gene Expression Regulation, Neoplastic HCC Humans Liver - pathology Liver Neoplasms - metabolism Liver Regeneration Membrane Proteins - physiology Mice Mice, Nude MicroRNA MicroRNAs - metabolism miR-376a p85α Transfection
Online-Zugang:	Volltext
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