Asymmetric Synthesis and Biosynthetic Implications of (+)-Fusarisetin A
Starting from equisetin, the asymmetric synthesis of (+)‐fusarisetin A has been accomplished in a one‐pot transformation including a biomimetic oxidation and an intramolecular Diels–Alder/Roskamp reaction. Peroxyfusarisetin is proposed as a plausible biosynthetic intermediate based on studies of the...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2012-07, Vol.51 (31), p.7786-7789 |
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| container_end_page | 7789 |
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| container_issue | 31 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Yin, Jun Wang, Cheng Kong, Lili Cai, Shujun Gao, Shuanhu |
| description | Starting from equisetin, the asymmetric synthesis of (+)‐fusarisetin A has been accomplished in a one‐pot transformation including a biomimetic oxidation and an intramolecular Diels–Alder/Roskamp reaction. Peroxyfusarisetin is proposed as a plausible biosynthetic intermediate based on studies of the oxidation of equisetin. |
| doi_str_mv | 10.1002/anie.201202455 |
| format | Article |
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| language | eng |
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| subjects | biosynthesis Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - metabolism Molecular Conformation natural products peroxides radical reactions Stereoisomerism total synthesis |
| title | Asymmetric Synthesis and Biosynthetic Implications of (+)-Fusarisetin A |
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