Decreased response to cAMP in the glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats

The hepatic response to cyclic adenosine monophosphate (cAMP) and N6-monobutyryl-cAMP (N6-MB-cAMP) in the glucose and glycogen catabolism and hepatic glycogen levels were evaluated in Walker-256 tumor-bearing rats, on days 5 (WK5), 8 (WK8), and 11 (WK11) after the implantation of tumor. Rats without...

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Veröffentlicht in:Molecular and cellular biochemistry 2012-09, Vol.368 (1-2), p.9-16
Hauptverfasser: de Morais, Hely, Cassola, Priscila, Moreira, Carolina Campos Lima, Bôas, Suéllen Kathiane Fernandes Vilas, Borba-Murad, Glaucia Regina, Bazotte, Roberto Barbosa, de Souza, Helenir Medri
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creator de Morais, Hely
Cassola, Priscila
Moreira, Carolina Campos Lima
Bôas, Suéllen Kathiane Fernandes Vilas
Borba-Murad, Glaucia Regina
Bazotte, Roberto Barbosa
de Souza, Helenir Medri
description The hepatic response to cyclic adenosine monophosphate (cAMP) and N6-monobutyryl-cAMP (N6-MB-cAMP) in the glucose and glycogen catabolism and hepatic glycogen levels were evaluated in Walker-256 tumor-bearing rats, on days 5 (WK5), 8 (WK8), and 11 (WK11) after the implantation of tumor. Rats without tumor fed ad libitum (fed control rats) or that received the same daily amount of food ingested by anorexics tumor-bearing rats (pair-fed control rats) or 24 h fasted (fasted control rats) were used as controls. Glucose and glycogen catabolism were measured in perfused liver. Hepatic glycogen levels were lower ( p  
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Rats without tumor fed ad libitum (fed control rats) or that received the same daily amount of food ingested by anorexics tumor-bearing rats (pair-fed control rats) or 24 h fasted (fasted control rats) were used as controls. Glucose and glycogen catabolism were measured in perfused liver. Hepatic glycogen levels were lower ( p  &lt; 0.05) in WK5, WK8, and WK11 rats in comparison with fed control rats, but not in relation to the pair-fed control rats. However, the stimulatory effect of cAMP (3 and 9 μM) in the glycogen catabolism was lower ( p  &lt; 0.05), respectively, in WK5 and WK8 rats compared to the pair-fed and fed control rats. Accordingly, the suppressive effect of cAMP (6 μM) in the glucose catabolism, under condition of depletion of hepatic glycogen (24 h fast), was lower ( p  &lt; 0.05) in WK5 and WK11 rats than in fasted control rats. Similarly, the suppressive effect of N6-MB-cAMP (1 μM), a synthetic analogue of cAMP that it is not degraded by phosphodiesterase 3B (PDE3B), in the glucose catabolism was lower ( p  &lt; 0.05) in WK5 rats compared to fasted control rats. In conclusion, livers of Walker-256 tumor-bearing rats showed lower response to cAMP in the glucose and glycogen catabolism in various stages of tumor development (days 5, 8 and 11), which was probably not due to the lower hepatic glycogen levels nor due to the increased activity of PDE3B.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-012-1337-4</identifier><identifier>PMID: 22638647</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Cancer ; Carcinoma 256, Walker - metabolism ; Carcinoma 256, Walker - pathology ; Cardiology ; Cyclic AMP - metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism ; Dextrose ; Glucose ; Glucose - metabolism ; Glycogen ; Glycogen - metabolism ; Glycogen - pharmacology ; Life Sciences ; Liver - metabolism ; Liver - pathology ; Male ; Medical Biochemistry ; Metabolism ; Neoplasm Proteins - metabolism ; Oncology ; Rats ; Rats, Wistar ; Rodents ; Time Factors ; Tumors</subject><ispartof>Molecular and cellular biochemistry, 2012-09, Vol.368 (1-2), p.9-16</ispartof><rights>Springer Science+Business Media, LLC. 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-fb79098e476d4d5ebfd5a8741c110a242f0aab4ed9b4fa605be27c535222f6d33</citedby><cites>FETCH-LOGICAL-c369t-fb79098e476d4d5ebfd5a8741c110a242f0aab4ed9b4fa605be27c535222f6d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-012-1337-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-012-1337-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22638647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Morais, Hely</creatorcontrib><creatorcontrib>Cassola, Priscila</creatorcontrib><creatorcontrib>Moreira, Carolina Campos Lima</creatorcontrib><creatorcontrib>Bôas, Suéllen Kathiane Fernandes Vilas</creatorcontrib><creatorcontrib>Borba-Murad, Glaucia Regina</creatorcontrib><creatorcontrib>Bazotte, Roberto Barbosa</creatorcontrib><creatorcontrib>de Souza, Helenir Medri</creatorcontrib><title>Decreased response to cAMP in the glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>The hepatic response to cyclic adenosine monophosphate (cAMP) and N6-monobutyryl-cAMP (N6-MB-cAMP) in the glucose and glycogen catabolism and hepatic glycogen levels were evaluated in Walker-256 tumor-bearing rats, on days 5 (WK5), 8 (WK8), and 11 (WK11) after the implantation of tumor. Rats without tumor fed ad libitum (fed control rats) or that received the same daily amount of food ingested by anorexics tumor-bearing rats (pair-fed control rats) or 24 h fasted (fasted control rats) were used as controls. Glucose and glycogen catabolism were measured in perfused liver. Hepatic glycogen levels were lower ( p  &lt; 0.05) in WK5, WK8, and WK11 rats in comparison with fed control rats, but not in relation to the pair-fed control rats. However, the stimulatory effect of cAMP (3 and 9 μM) in the glycogen catabolism was lower ( p  &lt; 0.05), respectively, in WK5 and WK8 rats compared to the pair-fed and fed control rats. Accordingly, the suppressive effect of cAMP (6 μM) in the glucose catabolism, under condition of depletion of hepatic glycogen (24 h fast), was lower ( p  &lt; 0.05) in WK5 and WK11 rats than in fasted control rats. 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Rats without tumor fed ad libitum (fed control rats) or that received the same daily amount of food ingested by anorexics tumor-bearing rats (pair-fed control rats) or 24 h fasted (fasted control rats) were used as controls. Glucose and glycogen catabolism were measured in perfused liver. Hepatic glycogen levels were lower ( p  &lt; 0.05) in WK5, WK8, and WK11 rats in comparison with fed control rats, but not in relation to the pair-fed control rats. However, the stimulatory effect of cAMP (3 and 9 μM) in the glycogen catabolism was lower ( p  &lt; 0.05), respectively, in WK5 and WK8 rats compared to the pair-fed and fed control rats. Accordingly, the suppressive effect of cAMP (6 μM) in the glucose catabolism, under condition of depletion of hepatic glycogen (24 h fast), was lower ( p  &lt; 0.05) in WK5 and WK11 rats than in fasted control rats. Similarly, the suppressive effect of N6-MB-cAMP (1 μM), a synthetic analogue of cAMP that it is not degraded by phosphodiesterase 3B (PDE3B), in the glucose catabolism was lower ( p  &lt; 0.05) in WK5 rats compared to fasted control rats. In conclusion, livers of Walker-256 tumor-bearing rats showed lower response to cAMP in the glucose and glycogen catabolism in various stages of tumor development (days 5, 8 and 11), which was probably not due to the lower hepatic glycogen levels nor due to the increased activity of PDE3B.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22638647</pmid><doi>10.1007/s11010-012-1337-4</doi><tpages>8</tpages></addata></record>
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subjects Animals
Biochemistry
Biomedical and Life Sciences
Cancer
Carcinoma 256, Walker - metabolism
Carcinoma 256, Walker - pathology
Cardiology
Cyclic AMP - metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism
Dextrose
Glucose
Glucose - metabolism
Glycogen
Glycogen - metabolism
Glycogen - pharmacology
Life Sciences
Liver - metabolism
Liver - pathology
Male
Medical Biochemistry
Metabolism
Neoplasm Proteins - metabolism
Oncology
Rats
Rats, Wistar
Rodents
Time Factors
Tumors
title Decreased response to cAMP in the glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats
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