Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice

Adenosine A(1) receptor (A(1)AR) agonists have antinociceptive effects in multiple preclinical models of acute and chronic pain. Although numerous A(1)AR agonists have been developed, clinical applications of these agents have been hampered by their cardiovascular side effects. Herein we report a se...

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Veröffentlicht in:	Journal of medicinal chemistry 2012-07, Vol.55 (14), p.6467-6477
Hauptverfasser:	Korboukh, Ilia, Hull-Ryde, Emily A, Rittiner, Joseph E, Randhawa, Amarjit S, Coleman, Jennifer, Fitzpatrick, Brendan J, Setola, Vincent, Janzen, William P, Frye, Stephen V, Zylka, Mark J, Jin, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A1 Receptor Agonists - administration & dosage Adenosine A1 Receptor Agonists - chemistry Adenosine A1 Receptor Agonists - metabolism Adenosine A1 Receptor Agonists - pharmacology Adenosine Monophosphate - administration & dosage Adenosine Monophosphate - chemistry Adenosine Monophosphate - metabolism Adenosine Monophosphate - pharmacology Administration, Oral Analgesics - administration & dosage Analgesics - chemistry Analgesics - metabolism Analgesics - pharmacology Animals Behavior, Animal - drug effects HEK293 Cells Humans Male Mice Nociception - drug effects Receptor, Adenosine A1 - metabolism Substrate Specificity Temperature
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