Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-08, Vol.48 (67), p.8332-8334
Hauptverfasser:	Nomikou, Nikolitsa, Fowley, Colin, Byrne, Niall M, McCaughan, Bridgeen, McHale, Anthony P, Callan, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Drug Delivery Systems Humans Microbubbles - therapeutic use Models, Biological Molecular Structure Neoplasms - therapy Rose Bengal - chemistry Ultrasonography
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc33913g