Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends

Both 5-fluorouracil (5-FU) and leucovorin (LV) are hydrophilic drugs which are used in combination for the treatment of colon cancer. Chitosan (CS) nanoparticles were prepared by ionic gelation technology, and then used for trapping 5-FU and LV. Combination drugs were encapsulated into CS nanopartic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carbohydrate polymers 2011-06, Vol.85 (3), p.698-704
Hauptverfasser:	Li, Puwang, Wang, Yichao, Peng, Zheng, She, Fenghua, Kong, Lingxue
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Applied sciences Biological and medical sciences Carbohydrates chitosan Chitosan nanoparticles Colon cancer colorectal neoplasms Combination chemotherapy Drug delivery Drug delivery system drug delivery systems electrostatic interactions Electrostatic properties Encapsulation Exact sciences and technology fluorouracil Fourier transform infrared spectroscopy Gelation General pharmacology hydrophilicity I.R. spectroscopy in vitro studies Medical sciences nanoparticles Natural polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Starch and polysaccharides Trapping X-ray diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!