Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar experiences). Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change. Specifically...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2011-05, Vol.108 (21), p.8873-8878 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8878 |
|---|---|
| container_issue | 21 |
| container_start_page | 8873 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 108 |
| creator | Yassa, Michael A Mattfeld, Aaron T Stark, Shauna M Stark, Craig E.L |
| description | Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar experiences). Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change. Specifically, these studies identified rigidity in place cell remapping in similar environments in the CA3. We used high-resolution fMRI to examine activity profiles in the dentate gyrus and CA3 in young and older adults as stimulus similarity was incrementally varied. We report evidence for "representational rigidity" in older adults' dentate/CA3 that is linked to behavioral discrimination deficits. Using ultrahigh-resolution diffusion imaging, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes and found that both were correlated with dentate/CA3 functional rigidity. These results highlight structural and functional alterations in the hippocampal network that predict age-related changes in memory function and present potential targets for intervention. |
| doi_str_mv | 10.1073/pnas.1101567108 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1028076746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25831045</jstor_id><sourcerecordid>25831045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-b0394afbbd7d114d0b8f22040932ca627d533b375ba1b69973cec90233ebf91f3</originalsourceid><addsrcrecordid>eNp9kctv1DAQhy0EotvCmRMQcYFL2vEjflyQqqo8pEocYM-W4zi7XpI42A5S_3u82qULHPDFkuebT-P5IfQCwyUGQa_myaRLjAE3XGCQj9AKg8I1ZwoeoxUAEbVkhJ2h85R2AKAaCU_RGcFNORKv0Pp64-roBpNdV41uDPG-6lzvrc-pGvz0vTznUFkf7eJznWZnfalWnU9xmbMPU6r8VOWtq7Z-noM147ykZ-hJb4bknh_vC7T-cPvt5lN99-Xj55vru9o2Uua6BaqY6du2Ex3GrINW9oQAA0WJNZyIrqG0paJpDW65UoJaZxUQSl3bK9zTC_T-4J2XdnSddVOOZtBz9KOJ9zoYr_-uTH6rN-GnprhYOCmCt0dBDD8Wl7IefbJuGMzkwpK05FJwoQQr5Lv_kkUoobCMF_TNP-guLHEqi9j7FGaKyAJdHSAbQ0rR9Q9TY9D7bPU-W33KtnS8-vOzD_zvMAvw-gjsO086WRAtpaCFeHkgdimHeDI0siyENSdDb4I2m-iTXn8lgDkAViUZSn8BQFq9pg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>868914928</pqid></control><display><type>article</type><title>Age-related memory deficits linked to circuit-specific disruptions in the hippocampus</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Yassa, Michael A ; Mattfeld, Aaron T ; Stark, Shauna M ; Stark, Craig E.L</creator><creatorcontrib>Yassa, Michael A ; Mattfeld, Aaron T ; Stark, Shauna M ; Stark, Craig E.L</creatorcontrib><description>Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar experiences). Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change. Specifically, these studies identified rigidity in place cell remapping in similar environments in the CA3. We used high-resolution fMRI to examine activity profiles in the dentate gyrus and CA3 in young and older adults as stimulus similarity was incrementally varied. We report evidence for "representational rigidity" in older adults' dentate/CA3 that is linked to behavioral discrimination deficits. Using ultrahigh-resolution diffusion imaging, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes and found that both were correlated with dentate/CA3 functional rigidity. These results highlight structural and functional alterations in the hippocampal network that predict age-related changes in memory function and present potential targets for intervention.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1101567108</identifier><identifier>PMID: 21555581</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adult ; Age ; Aging ; Biological Sciences ; Brain ; CA3 Region, Hippocampal - physiopathology ; Cells ; Data processing ; Dentate gyrus ; Dentate Gyrus - physiopathology ; Diffusion ; elderly ; Functional magnetic resonance imaging ; Hippocampus ; Hippocampus - physiopathology ; Humans ; image analysis ; loci ; Magnetic Resonance Imaging ; Memory ; Memory Disorders - physiopathology ; Neurogenesis ; Neurons ; NMR ; Nuclear magnetic resonance ; Older adults ; Perforant paths ; Perforant pathway ; Perforant Pathway - physiopathology ; rodents ; Structure-function relationships ; Young Adult ; Young adults</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (21), p.8873-8878</ispartof><rights>Copyright National Academy of Sciences May 24, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-b0394afbbd7d114d0b8f22040932ca627d533b375ba1b69973cec90233ebf91f3</citedby><cites>FETCH-LOGICAL-c588t-b0394afbbd7d114d0b8f22040932ca627d533b375ba1b69973cec90233ebf91f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/108/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25831045$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25831045$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21555581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yassa, Michael A</creatorcontrib><creatorcontrib>Mattfeld, Aaron T</creatorcontrib><creatorcontrib>Stark, Shauna M</creatorcontrib><creatorcontrib>Stark, Craig E.L</creatorcontrib><title>Age-related memory deficits linked to circuit-specific disruptions in the hippocampus</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar experiences). Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change. Specifically, these studies identified rigidity in place cell remapping in similar environments in the CA3. We used high-resolution fMRI to examine activity profiles in the dentate gyrus and CA3 in young and older adults as stimulus similarity was incrementally varied. We report evidence for "representational rigidity" in older adults' dentate/CA3 that is linked to behavioral discrimination deficits. Using ultrahigh-resolution diffusion imaging, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes and found that both were correlated with dentate/CA3 functional rigidity. These results highlight structural and functional alterations in the hippocampal network that predict age-related changes in memory function and present potential targets for intervention.</description><subject>Adult</subject><subject>Age</subject><subject>Aging</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>CA3 Region, Hippocampal - physiopathology</subject><subject>Cells</subject><subject>Data processing</subject><subject>Dentate gyrus</subject><subject>Dentate Gyrus - physiopathology</subject><subject>Diffusion</subject><subject>elderly</subject><subject>Functional magnetic resonance imaging</subject><subject>Hippocampus</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>image analysis</subject><subject>loci</subject><subject>Magnetic Resonance Imaging</subject><subject>Memory</subject><subject>Memory Disorders - physiopathology</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Older adults</subject><subject>Perforant paths</subject><subject>Perforant pathway</subject><subject>Perforant Pathway - physiopathology</subject><subject>rodents</subject><subject>Structure-function relationships</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctv1DAQhy0EotvCmRMQcYFL2vEjflyQqqo8pEocYM-W4zi7XpI42A5S_3u82qULHPDFkuebT-P5IfQCwyUGQa_myaRLjAE3XGCQj9AKg8I1ZwoeoxUAEbVkhJ2h85R2AKAaCU_RGcFNORKv0Pp64-roBpNdV41uDPG-6lzvrc-pGvz0vTznUFkf7eJznWZnfalWnU9xmbMPU6r8VOWtq7Z-noM147ykZ-hJb4bknh_vC7T-cPvt5lN99-Xj55vru9o2Uua6BaqY6du2Ex3GrINW9oQAA0WJNZyIrqG0paJpDW65UoJaZxUQSl3bK9zTC_T-4J2XdnSddVOOZtBz9KOJ9zoYr_-uTH6rN-GnprhYOCmCt0dBDD8Wl7IefbJuGMzkwpK05FJwoQQr5Lv_kkUoobCMF_TNP-guLHEqi9j7FGaKyAJdHSAbQ0rR9Q9TY9D7bPU-W33KtnS8-vOzD_zvMAvw-gjsO086WRAtpaCFeHkgdimHeDI0siyENSdDb4I2m-iTXn8lgDkAViUZSn8BQFq9pg</recordid><startdate>20110524</startdate><enddate>20110524</enddate><creator>Yassa, Michael A</creator><creator>Mattfeld, Aaron T</creator><creator>Stark, Shauna M</creator><creator>Stark, Craig E.L</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110524</creationdate><title>Age-related memory deficits linked to circuit-specific disruptions in the hippocampus</title><author>Yassa, Michael A ; Mattfeld, Aaron T ; Stark, Shauna M ; Stark, Craig E.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-b0394afbbd7d114d0b8f22040932ca627d533b375ba1b69973cec90233ebf91f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aging</topic><topic>Biological Sciences</topic><topic>Brain</topic><topic>CA3 Region, Hippocampal - physiopathology</topic><topic>Cells</topic><topic>Data processing</topic><topic>Dentate gyrus</topic><topic>Dentate Gyrus - physiopathology</topic><topic>Diffusion</topic><topic>elderly</topic><topic>Functional magnetic resonance imaging</topic><topic>Hippocampus</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>image analysis</topic><topic>loci</topic><topic>Magnetic Resonance Imaging</topic><topic>Memory</topic><topic>Memory Disorders - physiopathology</topic><topic>Neurogenesis</topic><topic>Neurons</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Older adults</topic><topic>Perforant paths</topic><topic>Perforant pathway</topic><topic>Perforant Pathway - physiopathology</topic><topic>rodents</topic><topic>Structure-function relationships</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yassa, Michael A</creatorcontrib><creatorcontrib>Mattfeld, Aaron T</creatorcontrib><creatorcontrib>Stark, Shauna M</creatorcontrib><creatorcontrib>Stark, Craig E.L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yassa, Michael A</au><au>Mattfeld, Aaron T</au><au>Stark, Shauna M</au><au>Stark, Craig E.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related memory deficits linked to circuit-specific disruptions in the hippocampus</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2011-05-24</date><risdate>2011</risdate><volume>108</volume><issue>21</issue><spage>8873</spage><epage>8878</epage><pages>8873-8878</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar experiences). Several studies have proposed the dentate and CA3 subfields of the hippocampus as the potential locus of this change. Specifically, these studies identified rigidity in place cell remapping in similar environments in the CA3. We used high-resolution fMRI to examine activity profiles in the dentate gyrus and CA3 in young and older adults as stimulus similarity was incrementally varied. We report evidence for "representational rigidity" in older adults' dentate/CA3 that is linked to behavioral discrimination deficits. Using ultrahigh-resolution diffusion imaging, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes and found that both were correlated with dentate/CA3 functional rigidity. These results highlight structural and functional alterations in the hippocampal network that predict age-related changes in memory function and present potential targets for intervention.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>21555581</pmid><doi>10.1073/pnas.1101567108</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (21), p.8873-8878 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1028076746 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Aging Biological Sciences Brain CA3 Region, Hippocampal - physiopathology Cells Data processing Dentate gyrus Dentate Gyrus - physiopathology Diffusion elderly Functional magnetic resonance imaging Hippocampus Hippocampus - physiopathology Humans image analysis loci Magnetic Resonance Imaging Memory Memory Disorders - physiopathology Neurogenesis Neurons NMR Nuclear magnetic resonance Older adults Perforant paths Perforant pathway Perforant Pathway - physiopathology rodents Structure-function relationships Young Adult Young adults |
| title | Age-related memory deficits linked to circuit-specific disruptions in the hippocampus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T00%3A32%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20memory%20deficits%20linked%20to%20circuit-specific%20disruptions%20in%20the%20hippocampus&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Yassa,%20Michael%20A&rft.date=2011-05-24&rft.volume=108&rft.issue=21&rft.spage=8873&rft.epage=8878&rft.pages=8873-8878&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1101567108&rft_dat=%3Cjstor_proqu%3E25831045%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=868914928&rft_id=info:pmid/21555581&rft_jstor_id=25831045&rfr_iscdi=true |