PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2

► We determined the structure of PHD in a rice SUMO ligase Siz1 (OsSiz1–PHD) by NMR. ► OsSiz1–PHD primarily recognizes dimethylated Arg2 of histone H3. ► Methylations at Arg2 and Lys4 of H3 show synergy effect on binding to OsSiz1–PHD. ► 3D NMR models of H3K4me3- and H3R2me2a–OsSiz1–PHD complexes ar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2012-06, Vol.586 (13), p.1783-1789
Hauptverfasser:	Shindo, Heisaburo, Suzuki, Rintaro, Tsuchiya, Wataru, Taichi, Misako, Nishiuchi, Yuji, Yamazaki, Toshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - genetics Arginine - metabolism Binding Sites Histones - chemistry Histones - metabolism Ligases - chemistry Ligases - metabolism Lysine - genetics Lysine - metabolism Methylated histone H3 Methylation Models, Molecular NMR structure Oryza - enzymology Oryza - metabolism Oryza sativa PHD finger Plant Proteins - chemistry Plant Proteins - metabolism Protein Conformation Protein–peptide interaction SUMO ligase Siz/PIAS Sumoylation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!