Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits

Fragile X syndrome (FXS) is a common cause of inherited intellectual disability and a well‐characterized form of autism spectrum disorder. As brain‐derived neurotrophic factor (BDNF) is implicated in the pathophysiology of FXS we examined the effects of reduced BDNF expression on the behavioral phen...

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Veröffentlicht in:	Genes, brain and behavior brain and behavior, 2012-07, Vol.11 (5), p.513-523
Hauptverfasser:	Uutela, M., Lindholm, J., Louhivuori, V., Wei, H., Louhivuori, L. M., Pertovaara, A., Åkerman, K., Castrén, E., Castrén, M. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADHD Age Animal models Animals Autism Axons Behavior, Animal Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell survival Cells, Cultured Cognition Disorders - genetics Cognition Disorders - metabolism Cognitive ability Conditioning (Psychology) - physiology Fear Fear - physiology FMR1 protein FMRP fragile X mental retardation protein Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X syndrome Gait Disorders, Neurologic - genetics Gait Disorders, Neurologic - metabolism Gene deletion Genotype & phenotype Hippocampus Hippocampus - metabolism Hyperactivity Hyperkinesis - genetics Hyperkinesis - metabolism Hypersensitivity Maze learning Maze Learning - physiology Mental retardation Mice Mice, Knockout Motor Activity - genetics Neonates Neural Stem Cells neurites Neurons - metabolism Obesity Pain perception Proteins Reflex, Startle - genetics Rodents rotarod test sensorimotor system startle reflex water maze learning
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