Multiple genotoxic activities of ptaquiloside in human lymphocytes: Aneugenesis, clastogenesis and induction of sister chromatid exchange

Ptaquiloside, a norsesquiterpene glycoside from bracken (Pteridium aquilinum), is a known carcinogen towards animals. Its genotoxicity is mainly attributed to its DNA-alkylating and clastogenic properties. This study analyses various modes of genotoxic action of ptaquiloside in human mononuclear blo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mutation research 2012-08, Vol.747 (1), p.77-81
Hauptverfasser:	Gil da Costa, Rui M., Coelho, Patrícia, Sousa, Rosa, Bastos, Margarida M.S.M., Porto, Beatriz, Teixeira, João P., Malheiro, Isabel, Lopes, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - toxicity Aneugens - toxicity Aneuploidy Bioassays Bracken Carcinogens Clastogenesis Comet Assay Cytogenetics Cytotoxicity DNA damage DNA Damage - drug effects Dose-Response Relationship, Drug Humans Indans - toxicity Lymphocytes Lymphocytes - drug effects Mutagens - toxicity Ptaquiloside Pteridium aquilinum SCE Sesquiterpenes - toxicity Sister Chromatid Exchange - drug effects Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!