Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion

► IR injury reduces the global 5hmC level in mouse kidney. ► IR injury decreases the 5hmC enrichment at two gene loci in mouse kidney. ► Tet2 expression is down-regulated in IR-insulted mouse kidney. Ischemia reperfusion (IR) is a frequent pathological injury to the perioperative patients. The molec...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-06, Vol.422 (4), p.697-702
Hauptverfasser:	Huang, Ning, Tan, Li, Xue, Zhanggang, Cang, Jing, Wang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives Animals Chemokine CXCL10 - genetics CXCL10 protein Cytosine - analogs & derivatives Cytosine - metabolism Data processing Disease Models, Animal DNA DNA hydroxymethylation DNA Methylation DNA-Binding Proteins - genetics Gene expression Gene Expression Regulation Gene regulation Immunochemistry Injuries Ischemia Ischemia reperfusion Kidney Kidney - blood supply Male Mice Mice, Inbred C57BL Molecular modelling Mouse kidney Promoters Proto-Oncogene Proteins - genetics Receptors, Interferon - genetics Reperfusion Reperfusion Injury - genetics tet gene Tet2 Transcription
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