Role of DNA methyltransferase 3A mRNA expression in Egyptian patients with idiopathic thrombocytopenic purpura

Introduction: Idiopathic thrombocytopenic purpura (ITP) is an organ‐specific autoimmune hemorrhagic disease characterized by breakdown of self‐tolerance and triggering autoreactive lymphocytes’ response against platelets. The underlying etiology of ITP remains largely unknown. DNA methylation plays...

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Veröffentlicht in:	International journal of laboratory hematology 2012-08, Vol.34 (4), p.369-376
Hauptverfasser:	EL-SHIEKH, E. H., BESSA, S. S., ABDOU, S. M., EL-REFAEY, W. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoimmunity Chromatography, High Pressure Liquid DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA methyltransferase DNA methyltransferase 3A Egypt epigenetics Etiology Female Gene expression Gene Expression Regulation, Enzymologic Hemorrhagic disease High-performance liquid chromatography Humans Idiopathic thrombocytopenic purpura Immunological tolerance Lymphocytes Lymphocytes T Male Peripheral blood mononuclear cells Platelets Polymerase Chain Reaction Purpura, Thrombocytopenic, Idiopathic - enzymology Purpura, Thrombocytopenic, Idiopathic - genetics RNA, Messenger - metabolism S-adenosylhomocysteine
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