Sensitivity of modified Biel-maze task, compared with Y-maze task, to measure spatial learning and memory deficits of ethanol teratogenicity in the guinea pig

► Chronic prenatal ethanol exposure induces neurobehavioral deficits in offspring. ► Complex spatial working memory tasks improve sensitivity for detecting cognitive deficits. ► Speed accuracy trade-off increases frequency of errors in a spatial working memory task. Ethanol consumption during pregna...

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Veröffentlicht in:	Behavioural brain research 2012-07, Vol.233 (1), p.162-168
Hauptverfasser:	Dobson, Christine C., Mongillo, Daniel L., Poklewska-Koziell, Margo, Winterborn, Andrew, Brien, James F., Reynolds, James N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Analysis of Variance Animals Biel maze Body weight Brain Brain - drug effects Central Nervous System Depressants - toxicity Cognitive ability Ethanol Ethanol - toxicity Ethanol neurobehavioral teratogenicity Female Fetal alcohol spectrum disorders Fetal alcohol syndrome Gestation Guinea pig Guinea Pigs Locomotor activity Male Maze Learning - drug effects Memory Memory Disorders - chemically induced Memory Disorders - pathology Motor Activity - drug effects Pregnancy Prenatal experience Prenatal Exposure Delayed Effects - physiopathology Progeny Reward Space Perception - drug effects Spatial discrimination learning Spatial learning and memory spatial memory Sucrose - administration & dosage Sweetening Agents - administration & dosage Teratogenicity Time Factors Y-maze
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