Therapeutic siRNAs and nonviral systems for their delivery
Gene-directed therapy with small interfering RNA (siRNA) has a tremendous potential and will undoubtedly occupy one of the leading positions among other therapeutic methods in the future. The lack of efficient and targeted delivery vectors delays a successful implementation of this method in medicin...
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| Veröffentlicht in: | Molecular biology (New York) 2012-05, Vol.46 (3), p.335-348 |
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| container_title | Molecular biology (New York) |
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| creator | Glebova, K. V. Marakhonov, A. V. Baranova, A. V. Skoblov, M. Yu |
| description | Gene-directed therapy with small interfering RNA (siRNA) has a tremendous potential and will undoubtedly occupy one of the leading positions among other therapeutic methods in the future. The lack of efficient and targeted delivery vectors delays a successful implementation of this method in medicine. To develop such systems, one needs a comprehensive insight into the interactions of siRNAs, its delivery systems, and an organism. The review covers the properties of therapeutic siRNAs and nonviral systems for their delivery. |
| doi_str_mv | 10.1134/S0026893312020069 |
| format | Article |
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| ispartof | Molecular biology (New York), 2012-05, Vol.46 (3), p.335-348 |
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| subjects | Biochemistry Biomedical and Life Sciences Gene therapy Human Genetics Life Sciences Molecular biology Molecular Biomedicine Special Issue Pharmacology Reviews Ribonucleic acid RNA siRNA |
| title | Therapeutic siRNAs and nonviral systems for their delivery |
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