Therapeutic siRNAs and nonviral systems for their delivery

Gene-directed therapy with small interfering RNA (siRNA) has a tremendous potential and will undoubtedly occupy one of the leading positions among other therapeutic methods in the future. The lack of efficient and targeted delivery vectors delays a successful implementation of this method in medicin...

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Veröffentlicht in:	Molecular biology (New York) 2012-05, Vol.46 (3), p.335-348
Hauptverfasser:	Glebova, K. V., Marakhonov, A. V., Baranova, A. V., Skoblov, M. Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Gene therapy Human Genetics Life Sciences Molecular biology Molecular Biomedicine Special Issue Pharmacology Reviews Ribonucleic acid RNA siRNA
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Gene-directed therapy with small interfering RNA (siRNA) has a tremendous potential and will undoubtedly occupy one of the leading positions among other therapeutic methods in the future. The lack of efficient and targeted delivery vectors delays a successful implementation of this method in medicine. To develop such systems, one needs a comprehensive insight into the interactions of siRNAs, its delivery systems, and an organism. The review covers the properties of therapeutic siRNAs and nonviral systems for their delivery.
ISSN:	0026-8933 1608-3245
DOI:	10.1134/S0026893312020069