Reactive gliosis and neuroinflammation in rats with communicating hydrocephalus

Graphical abstract We confirmed that the degrees of astrocytpsis and microgliosis are positively related to the development of hydrocephalus and indicate a detrimental role of glial cells in hydrocephalus despite of the protective role of reactive gliosis. These results indicate that the cause of hy...

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Veröffentlicht in:	Neuroscience 2012-08, Vol.218, p.317-325
Hauptverfasser:	Xu, H, Zhang, S.L, Tan, G.W, Zhu, H.W, Huang, C.Q, Zhang, F.F, Wang, Z.X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biological and medical sciences Blotting, Western Brain Brain - pathology Brain - physiopathology Calcium Cerebrospinal fluid Cerebrospinal fluid. Meninges. Spinal cord Correlation analysis Disease Models, Animal Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene expression Glial fibrillary acidic protein Gliosis Gliosis - pathology Hydrocephalus Hydrocephalus - pathology Hydrocephalus - physiopathology Immunohistochemistry Inflammation Inflammation - pathology Injuries Interleukin 18 Kaolin Magnetic resonance imaging Male Medical sciences Nervous system (semeiology, syndromes) neuroinflammation Neurology pathogenesis Polymerase chain reaction Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Standard deviation Ventricles (cerebral) Vertebrates: nervous system and sense organs Western blotting
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