A thermoprotective role of the sodium channel β 1 subunit is lost with the β 1 (C121W) mutation

Purpose:  A mutation in the β 1 subunit of the voltage‐gated sodium (Na V ) channel, β 1 (C121W), causes genetic epilepsy with febrile seizures plus (GEFS+), a pediatric syndrome in which febrile seizures are the predominant phenotype. Previous studies of molecular mechanisms underlying neuronal hyp...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Epilepsia (Copenhagen) 2012-03, Vol.53 (3), p.494-505
Hauptverfasser:	Egri, Csilla, Vilin, Yuriy Y., Ruben, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Epilepsy Excitability Molecular modelling Mutation Pediatrics Seizures Sodium channels (voltage-gated) Temperature effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!