Current status of chemokine receptor inhibitors in development

Highlights ► Innovative drugs targeting CXC and CC receptors. ► Preclinical and clinical development of drugs acting on chemokine system. ► Perspectives on the development of novel Small Molecular Weight chemokine inhibitors.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2012-07, Vol.145 (1), p.68-78
Hauptverfasser:	Allegretti, Marcello, Cesta, Maria Candida, Garin, Alexandre, Proudfoot, Amanda E.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Allosteric inhibitors Animals Autoimmune diseases CC receptor antagonists Cell Movement - drug effects Chemokine Chemokine receptors Chemokines - immunology Clinical trials Clinical Trials as Topic CXC Drug Discovery HIV Humans Inflammation Inflammatory diseases Metastases Molecular Targeted Therapy Pharmaceuticals Receptors, Chemokine - antagonists & inhibitors Small Molecule Libraries Tumors
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Beschreibung
Zusammenfassung:	Highlights ► Innovative drugs targeting CXC and CC receptors. ► Preclinical and clinical development of drugs acting on chemokine system. ► Perspectives on the development of novel Small Molecular Weight chemokine inhibitors.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2012.04.003