Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population
Recent studies have suggested that common genetic polymorphisms alter the processing of microRNA (miRNA) and may be associated with the development and progression of cancer. The association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase...
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| Veröffentlicht in: | Gene 2012-08, Vol.504 (1), p.92-97 |
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| creator | Kim, Won Hee Min, Kyung Tae Jeon, Young Joo Kwon, Chang-Il Ko, Kwang Hyun Park, Pil Won Hong, Sung Pyo Rim, Kyu Seong Kwon, Sung Won Hwang, Seong Gyu Kim, Nam Keun |
| description | Recent studies have suggested that common genetic polymorphisms alter the processing of microRNA (miRNA) and may be associated with the development and progression of cancer.
The association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
The risk of HCC was significantly lower for the miR-499A>G, AG+GG in HCC patients (AOR=0.603, 95% CI=0.370–0.984) and hepatitis B virus (HBV)-related HCC patients (AOR=0.561, 95% CI 0.331–0.950). In addition, the risk of HCC was significantly lower for the miR-149C>T, CT and CT+CC in HCC patients (CT; AOR=0.542, 95% CI=0.332–0.886, CT+CC; AOR=0.536, 95% CI=0.335–0.858) and HBV-related HCC patients (CT: AOR=0.510, 95% CI 0.305–0.854, CT+CC: AOR=0.496, 95% CI 0.302–0.813). The miR-149C>T polymorphism was also associated with survival rate of HCC patients in OKUDA II stage.
miR-149C>T and miR-499A>G were associated with HBV-related HCC. Further studies on larger populations will need to be conducted to confirm these results.
► We investigated the association of four microRNA polymorphisms in Korean HCC patients. ► We could find the relation between miR-149C>T and miR-499A>G with occurrence of HCC. ► miR-149C>T and miR-499A>G may contribute to incidence of HCC. |
| doi_str_mv | 10.1016/j.gene.2012.05.014 |
| format | Article |
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The association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
The risk of HCC was significantly lower for the miR-499A>G, AG+GG in HCC patients (AOR=0.603, 95% CI=0.370–0.984) and hepatitis B virus (HBV)-related HCC patients (AOR=0.561, 95% CI 0.331–0.950). In addition, the risk of HCC was significantly lower for the miR-149C>T, CT and CT+CC in HCC patients (CT; AOR=0.542, 95% CI=0.332–0.886, CT+CC; AOR=0.536, 95% CI=0.335–0.858) and HBV-related HCC patients (CT: AOR=0.510, 95% CI 0.305–0.854, CT+CC: AOR=0.496, 95% CI 0.302–0.813). The miR-149C>T polymorphism was also associated with survival rate of HCC patients in OKUDA II stage.
miR-149C>T and miR-499A>G were associated with HBV-related HCC. Further studies on larger populations will need to be conducted to confirm these results.
► We investigated the association of four microRNA polymorphisms in Korean HCC patients. ► We could find the relation between miR-149C>T and miR-499A>G with occurrence of HCC. ► miR-149C>T and miR-499A>G may contribute to incidence of HCC.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2012.05.014</identifier><identifier>PMID: 22583825</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - virology ; Case-Control Studies ; DNA - genetics ; Female ; Gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Hepatitis B - epidemiology ; Hepatitis B - genetics ; Hepatitis B - mortality ; Hepatitis B - virology ; Hepatitis B virus ; Hepatitis B virus (HBV) ; Hepatitis B virus - isolation & purification ; Hepatocellular carcinoma ; Hepatocellular carcinoma (HCC) ; hepatoma ; Humans ; Liver - metabolism ; Liver - pathology ; Liver Neoplasms - epidemiology ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver Neoplasms - virology ; Male ; microRNA ; MicroRNA (miRNA) ; MicroRNAs - genetics ; Middle Aged ; miRNA ; patients ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide - genetics ; Population studies ; Prognosis ; Republic of Korea - epidemiology ; Restriction fragment length polymorphism ; risk ; Risk Factors ; Survival ; Survival Rate</subject><ispartof>Gene, 2012-08, Vol.504 (1), p.92-97</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-b15e360b6a3ad12ed3ae373aeaf020ee1edd8fb36db6bc7782e112de349987a83</citedby><cites>FETCH-LOGICAL-c413t-b15e360b6a3ad12ed3ae373aeaf020ee1edd8fb36db6bc7782e112de349987a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2012.05.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22583825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Won Hee</creatorcontrib><creatorcontrib>Min, Kyung Tae</creatorcontrib><creatorcontrib>Jeon, Young Joo</creatorcontrib><creatorcontrib>Kwon, Chang-Il</creatorcontrib><creatorcontrib>Ko, Kwang Hyun</creatorcontrib><creatorcontrib>Park, Pil Won</creatorcontrib><creatorcontrib>Hong, Sung Pyo</creatorcontrib><creatorcontrib>Rim, Kyu Seong</creatorcontrib><creatorcontrib>Kwon, Sung Won</creatorcontrib><creatorcontrib>Hwang, Seong Gyu</creatorcontrib><creatorcontrib>Kim, Nam Keun</creatorcontrib><title>Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population</title><title>Gene</title><addtitle>Gene</addtitle><description>Recent studies have suggested that common genetic polymorphisms alter the processing of microRNA (miRNA) and may be associated with the development and progression of cancer.
The association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
The risk of HCC was significantly lower for the miR-499A>G, AG+GG in HCC patients (AOR=0.603, 95% CI=0.370–0.984) and hepatitis B virus (HBV)-related HCC patients (AOR=0.561, 95% CI 0.331–0.950). In addition, the risk of HCC was significantly lower for the miR-149C>T, CT and CT+CC in HCC patients (CT; AOR=0.542, 95% CI=0.332–0.886, CT+CC; AOR=0.536, 95% CI=0.335–0.858) and HBV-related HCC patients (CT: AOR=0.510, 95% CI 0.305–0.854, CT+CC: AOR=0.496, 95% CI 0.302–0.813). The miR-149C>T polymorphism was also associated with survival rate of HCC patients in OKUDA II stage.
miR-149C>T and miR-499A>G were associated with HBV-related HCC. Further studies on larger populations will need to be conducted to confirm these results.
► We investigated the association of four microRNA polymorphisms in Korean HCC patients. ► We could find the relation between miR-149C>T and miR-499A>G with occurrence of HCC. ► miR-149C>T and miR-499A>G may contribute to incidence of HCC.</description><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Case-Control Studies</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - genetics</subject><subject>Hepatitis B - mortality</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus (HBV)</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatocellular carcinoma (HCC)</subject><subject>hepatoma</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - virology</subject><subject>Male</subject><subject>microRNA</subject><subject>MicroRNA (miRNA)</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>patients</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population studies</subject><subject>Prognosis</subject><subject>Republic of Korea - epidemiology</subject><subject>Restriction fragment length polymorphism</subject><subject>risk</subject><subject>Risk Factors</subject><subject>Survival</subject><subject>Survival Rate</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EokPhBViAl2wSfO048UhsRlX5ERVIQLdYjn3T8SiJg520mrfH0RSWVb2wF_7O0b3nEPIaWAkM6veH8gZHLDkDXjJZMqiekA2oZlswJtRTsmGiUQUAbM_Ii5QOLB8p-XNyxrlUQnG5Ib93KQXrzezDSNO8uCMNHR28jeHHtx2dQn8cQpz2Pg2J3vl5T_c4mTlY7PulN5FaE60fw2CoH-nXENGMWTXlv9XyJXnWmT7hq_v3nFx_vPx18bm4-v7py8XuqrAViLloQaKoWVsbYRxwdMKgaPJlOsYZIqBzqmtF7dq6tU2jOAJwh6LablVjlDgn706-Uwx_FkyzHnxaZzQjhiVpYFwx3jBgj0Gzd9VwyCg_oTmNlCJ2eop-MPGYIb1WoA96rUCvFWgmda4gi97c-y_tgO6_5F_mGXh7AjoTtLmJPunrn9lB5noqIet1mw8nAnNktx6jTtbjaNH5iHbWLviHJvgLZ3CiMw</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Kim, Won Hee</creator><creator>Min, Kyung Tae</creator><creator>Jeon, Young Joo</creator><creator>Kwon, Chang-Il</creator><creator>Ko, Kwang Hyun</creator><creator>Park, Pil Won</creator><creator>Hong, Sung Pyo</creator><creator>Rim, Kyu Seong</creator><creator>Kwon, Sung Won</creator><creator>Hwang, Seong Gyu</creator><creator>Kim, Nam Keun</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20120801</creationdate><title>Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population</title><author>Kim, Won Hee ; Min, Kyung Tae ; Jeon, Young Joo ; Kwon, Chang-Il ; Ko, Kwang Hyun ; Park, Pil Won ; Hong, Sung Pyo ; Rim, Kyu Seong ; Kwon, Sung Won ; Hwang, Seong Gyu ; Kim, Nam Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-b15e360b6a3ad12ed3ae373aeaf020ee1edd8fb36db6bc7782e112de349987a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Case-Control Studies</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - genetics</topic><topic>Hepatitis B - mortality</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus (HBV)</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatocellular carcinoma (HCC)</topic><topic>hepatoma</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - virology</topic><topic>Male</topic><topic>microRNA</topic><topic>MicroRNA (miRNA)</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>patients</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Population studies</topic><topic>Prognosis</topic><topic>Republic of Korea - epidemiology</topic><topic>Restriction fragment length polymorphism</topic><topic>risk</topic><topic>Risk Factors</topic><topic>Survival</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Won Hee</creatorcontrib><creatorcontrib>Min, Kyung Tae</creatorcontrib><creatorcontrib>Jeon, Young Joo</creatorcontrib><creatorcontrib>Kwon, Chang-Il</creatorcontrib><creatorcontrib>Ko, Kwang Hyun</creatorcontrib><creatorcontrib>Park, Pil Won</creatorcontrib><creatorcontrib>Hong, Sung Pyo</creatorcontrib><creatorcontrib>Rim, Kyu Seong</creatorcontrib><creatorcontrib>Kwon, Sung Won</creatorcontrib><creatorcontrib>Hwang, Seong Gyu</creatorcontrib><creatorcontrib>Kim, Nam Keun</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Won Hee</au><au>Min, Kyung Tae</au><au>Jeon, Young Joo</au><au>Kwon, Chang-Il</au><au>Ko, Kwang Hyun</au><au>Park, Pil Won</au><au>Hong, Sung Pyo</au><au>Rim, Kyu Seong</au><au>Kwon, Sung Won</au><au>Hwang, Seong Gyu</au><au>Kim, Nam Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>504</volume><issue>1</issue><spage>92</spage><epage>97</epage><pages>92-97</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Recent studies have suggested that common genetic polymorphisms alter the processing of microRNA (miRNA) and may be associated with the development and progression of cancer.
The association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
The risk of HCC was significantly lower for the miR-499A>G, AG+GG in HCC patients (AOR=0.603, 95% CI=0.370–0.984) and hepatitis B virus (HBV)-related HCC patients (AOR=0.561, 95% CI 0.331–0.950). In addition, the risk of HCC was significantly lower for the miR-149C>T, CT and CT+CC in HCC patients (CT; AOR=0.542, 95% CI=0.332–0.886, CT+CC; AOR=0.536, 95% CI=0.335–0.858) and HBV-related HCC patients (CT: AOR=0.510, 95% CI 0.305–0.854, CT+CC: AOR=0.496, 95% CI 0.302–0.813). The miR-149C>T polymorphism was also associated with survival rate of HCC patients in OKUDA II stage.
miR-149C>T and miR-499A>G were associated with HBV-related HCC. Further studies on larger populations will need to be conducted to confirm these results.
► We investigated the association of four microRNA polymorphisms in Korean HCC patients. ► We could find the relation between miR-149C>T and miR-499A>G with occurrence of HCC. ► miR-149C>T and miR-499A>G may contribute to incidence of HCC.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22583825</pmid><doi>10.1016/j.gene.2012.05.014</doi><tpages>6</tpages></addata></record> |
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| subjects | Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - virology Case-Control Studies DNA - genetics Female Gene polymorphism Genetic Predisposition to Disease Genotype Hepatitis B - epidemiology Hepatitis B - genetics Hepatitis B - mortality Hepatitis B - virology Hepatitis B virus Hepatitis B virus (HBV) Hepatitis B virus - isolation & purification Hepatocellular carcinoma Hepatocellular carcinoma (HCC) hepatoma Humans Liver - metabolism Liver - pathology Liver Neoplasms - epidemiology Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - virology Male microRNA MicroRNA (miRNA) MicroRNAs - genetics Middle Aged miRNA patients Polymerase Chain Reaction Polymorphism Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide - genetics Population studies Prognosis Republic of Korea - epidemiology Restriction fragment length polymorphism risk Risk Factors Survival Survival Rate |
| title | Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population |
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