Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release

Abstract A new type of redox/pH dual stimuli-responsive poly(methacrylic acid) (PMAA)-based nanohydrogels was prepared from methacrylic acid and N,N -bis(acryloyl)cystamine crosslinker via distillation-precipitation polymerization. The nanohydrogels could be easily degraded into individual linear sh...

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Veröffentlicht in:	Biomaterials 2012-09, Vol.33 (27), p.6570-6579
Hauptverfasser:	Pan, Yuan-Jia, Chen, Yuan-Yuan, Wang, Dong-Rui, Wei, Chuan, Guo, Jia, Lu, Da-Ru, Chu, Chih-Chang, Wang, Chang-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Biocompatible Materials - chemistry Biodegradable Biodegradation, Environmental Cell Line, Tumor Cell Survival - drug effects Cross-Linking Reagents - chemistry Delayed-Action Preparations Dentistry Distillation-precipitation polymerization Disulfides - chemistry Dithiothreitol - pharmacology Doxorubicin - chemistry Doxorubicin - pharmacology Drug delivery Glutathione - pharmacology HEK293 Cells Humans Hydrogels - chemistry Hydrogen-Ion Concentration - drug effects Microscopy, Fluorescence Microscopy, Phase-Contrast Nanohydrogel Nanoparticles - chemistry Nanoparticles - ultrastructure Oxidation-Reduction - drug effects pH-responsive Polymethacrylic Acids - chemistry Redox-responsive Spectroscopy, Fourier Transform Infrared
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