I?B Kinase ? Phosphorylation of TRAF4 Downregulates Innate Immune Signaling

Despite their homology, I Kappa B kinase alpha (IKK alpha ) and IKK beta have divergent roles in NF- Kappa B signaling. IKK beta strongly activates NF- Kappa B while IKK alpha can downregulate NF- Kappa B under certain circumstances. Given this, identifying independent substrates for these kinases c...

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Veröffentlicht in:	Molecular and cellular biology 2012-07, Vol.32 (13), p.2479-2489
Hauptverfasser:	Marinis, Jill M, Hutti, Jessica E, Homer, Craig R, Cobb, Brian A, Cantley, Lewis C, McDonald, Christine, Abbott, Derek W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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