Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro
In this study, the antigenotoxic and antioxidant effects of Umbilicaria vellea (UME) and Xantho somloensis (XME) extracts were determined using sister chromatid exchange (SCE), micronuclei (MN) assays, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MD...
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| Veröffentlicht in: | Toxicology and industrial health 2012-07, Vol.28 (6), p.505-512 |
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| creator | Aslan, Ali Agar, Guleray Alpsoy, Lokman Kotan, Elif Ceker, Selcuk |
| description | In this study, the antigenotoxic and antioxidant effects of Umbilicaria vellea (UME) and Xantho
somloensis (XME) extracts were determined using sister chromatid exchange (SCE), micronuclei (MN) assays, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against the effects of aflatoxin B1 (AFB1)-induced oxidative stress and genotoxicity in human lymphocytes in vitro. The results showed that the frequencies of SCE, MN, and MDA level decreased, but the activities of SOD and GPx increased when 5 μg/mL and 10 μg/mL doses of UME and XME were added to AFB1-treated cultures. Also the present results indicate that strong antioxidative and the antigenotoxicity mechanisms of UME and XME are associated with its antioxidant nature. |
| doi_str_mv | 10.1177/0748233711416944 |
| format | Article |
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somloensis (XME) extracts were determined using sister chromatid exchange (SCE), micronuclei (MN) assays, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against the effects of aflatoxin B1 (AFB1)-induced oxidative stress and genotoxicity in human lymphocytes in vitro. The results showed that the frequencies of SCE, MN, and MDA level decreased, but the activities of SOD and GPx increased when 5 μg/mL and 10 μg/mL doses of UME and XME were added to AFB1-treated cultures. Also the present results indicate that strong antioxidative and the antigenotoxicity mechanisms of UME and XME are associated with its antioxidant nature.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233711416944</identifier><identifier>PMID: 21986884</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aflatoxin B1 - toxicity ; Antioxidants ; Antioxidants - pharmacology ; Biology ; Cytotoxicity ; Glutathione Peroxidase - metabolism ; Humans ; Lichens ; Lichens - chemistry ; Lymphocytes ; Lymphocytes - drug effects ; Metabolites ; Methanol - chemistry ; Micronucleus Tests ; Mutagenicity Tests ; Mutagens - toxicity ; Plant Extracts - pharmacology ; Sister Chromatid Exchange - drug effects ; Superoxide Dismutase - metabolism ; Toxicology</subject><ispartof>Toxicology and industrial health, 2012-07, Vol.28 (6), p.505-512</ispartof><rights>The Author(s) 2011</rights><rights>SAGE Publications © Jul 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233711416944$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233711416944$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21986884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aslan, Ali</creatorcontrib><creatorcontrib>Agar, Guleray</creatorcontrib><creatorcontrib>Alpsoy, Lokman</creatorcontrib><creatorcontrib>Kotan, Elif</creatorcontrib><creatorcontrib>Ceker, Selcuk</creatorcontrib><title>Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>In this study, the antigenotoxic and antioxidant effects of Umbilicaria vellea (UME) and Xantho
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Also the present results indicate that strong antioxidative and the antigenotoxicity mechanisms of UME and XME are associated with its antioxidant nature.</description><subject>Adult</subject><subject>Aflatoxin B1 - toxicity</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Biology</subject><subject>Cytotoxicity</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Humans</subject><subject>Lichens</subject><subject>Lichens - chemistry</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Metabolites</subject><subject>Methanol - chemistry</subject><subject>Micronucleus Tests</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>Plant Extracts - pharmacology</subject><subject>Sister Chromatid Exchange - drug effects</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Toxicology</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkb1v2zAQxYkiQe243TsVBLJkUcsPiaTGJIiTAAGaoZ2FE3m2FUikI1KJvfYvj1S7QJGp0-He-90Bd4-QL5x941zr70znRkipOc-5KvP8A5nzXOuMyVKekPlkZ5M_I2cxPjHGlCrERzITvDTKmHxOfj_2IaFNzQvSPrRIw4p2mDbgQ0txl3qwKU5ieg20bewG_dh6GnaNgz9T4B1dow9plCx10MEaqYUhoqP1nl4urzhtPN0MHXja7rvtJth9wjiJL03qwydyuoI24udjXZBfy5uf13fZw4_b--vLh2wrRJEyu9IGnDSonOPMKJ1bbbHGUnEGGkWtlVSrAjQ4rR1jdc1lAdaI2hlgopQLcnHYu-3D84AxVV0TLbYteAxDrDgThomi4OZ_UMaN0UqN6Pk79CkMvR8POVBcsZyN1NcjNdQdumrbNx30--pvECOQHYA4vu_fFdUUdPU-aPkGIb-X6g</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Aslan, Ali</creator><creator>Agar, Guleray</creator><creator>Alpsoy, Lokman</creator><creator>Kotan, Elif</creator><creator>Ceker, Selcuk</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>201207</creationdate><title>Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro</title><author>Aslan, Ali ; Agar, Guleray ; Alpsoy, Lokman ; Kotan, Elif ; Ceker, Selcuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p225t-cf78ad38e6dd108674c7cebe9610a7e2b7636f5a7ad77d00bb135ac82bd8a0293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aflatoxin B1 - 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| ispartof | Toxicology and industrial health, 2012-07, Vol.28 (6), p.505-512 |
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| subjects | Adult Aflatoxin B1 - toxicity Antioxidants Antioxidants - pharmacology Biology Cytotoxicity Glutathione Peroxidase - metabolism Humans Lichens Lichens - chemistry Lymphocytes Lymphocytes - drug effects Metabolites Methanol - chemistry Micronucleus Tests Mutagenicity Tests Mutagens - toxicity Plant Extracts - pharmacology Sister Chromatid Exchange - drug effects Superoxide Dismutase - metabolism Toxicology |
| title | Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro |
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