A Search for SNCA 3′ UTR Variants Identified SNP rs356165 as a Determinant of Disease Risk and Onset Age in Parkinson’s Disease

Alpha-synuclein gene ( SNCA ) polymorphisms have been associated with the common sporadic form of Parkinson’s disease (PD). We searched for DNA variants at the SNCA 3′ UTR through single strand conformation analysis and direct sequencing in a cohort of Spanish PD patients and controls. We have genot...

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Veröffentlicht in:	Journal of molecular neuroscience 2012-07, Vol.47 (3), p.425-430
Hauptverfasser:	Cardo, Lucía F., Coto, Eliecer, de Mena, Lorena, Ribacoba, René, Lorenzo-Betancor, Oswaldo, Pastor, Pau, Samaranch, LLuis, Mata, Ignacio F., Díaz, Marta, Moris, Germán, Menéndez, Manuel, Corao, Ana I., Alvarez, Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adult Age Age of Onset Aged alpha-Synuclein - genetics Biomedical and Life Sciences Biomedicine Cell Biology Chi-square test Conformation DNA sequencing Family medical history Female Gene polymorphism Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genetic Variation - genetics Health risk assessment Humans Male Middle Aged Movement disorders Mutation Nervous system Neurochemistry Neurodegenerative diseases Neurology Neurosciences Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Polymorphism Polymorphism, Single Nucleotide - genetics Proteomics Risk Factors Single-nucleotide polymorphism Spain - epidemiology Synuclein
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