Causes and consequences of aneuploidy in cancer

Key Points Genomic instability, including whole-chromosome aneuploidy, is a hallmark of cancer. The disruption of multiple pathways, including defects in kinetochore–microtubule attachments and dynamics, centrosome number, spindle assembly checkpoint (SAC) and chromosome cohesion, can lead to aneupl...

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Veröffentlicht in:	Nature reviews. Genetics 2012-03, Vol.13 (3), p.189-203
Hauptverfasser:	Gordon, David J., Resio, Benjamin, Pellman, David
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/211 631/208/2489/1381/1286 68 692/699/67 Agriculture Aneuploidy Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - pathology Chromosomal Instability Chromosome Aberrations Chromosomes Complications and side effects Development and progression Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Genomes Human Genetics Humans Medical genetics Medical sciences Molecular and cellular biology Neoplasms - genetics Neoplasms - therapy review-article Tumorigenesis
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