A pharmacogenetic study of risperidone on histamine H3 receptor gene (HRH3) in Chinese Han schizophrenia patients

Evidence suggests that the human histamine H3 receptor (HRH3) may be involved in the pharmacodynamics of risperidone and influence clinical efficacy. More information on the pharmacogenetics of this receptor may therefore be useful in developing individualized therapy. However, to our knowledge, no...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2012-06, Vol.26 (6), p.813-818
Hauptverfasser:	Wei, Zhiyun, Wang, Lei, Zhang, Mengmeng, Xuan, Jiekun, Wang, Yang, Liu, Baocheng, Shao, Liyan, Li, Jun, Zeng, Zhen, Li, Tao, Liu, Jie, Wang, Ti, Zhang, Ming, Qin, Shengying, Xu, Yifeng, Feng, Guoyin, He, Lin, Xing, Qinghe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Asian Continental Ancestry Group - genetics Asian people Biological and medical sciences Brief Psychiatric Rating Scale Female Gene polymorphism Genetic markers Genetics Genotype Histamine Histamine H3 receptors Humans Male Medical sciences Mental disorders Neuroleptics Neuropharmacology Pharmacodynamics Pharmacogenetics Pharmacogenetics - methods Pharmacology. Drug treatments Polymorphism, Single Nucleotide Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Psychotropic drugs Receptors, Histamine H3 - genetics Risperidone Risperidone - therapeutic use Schizophrenia Schizophrenia - drug therapy Schizophrenia - genetics Single-nucleotide polymorphism Statistical analysis
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